Epilepsy
| Eishi Asano, M.D., Ph.D. | Pediatrics, Neurology |
| Alan Dombkowski, Ph.D. | Pediatrics |
| Csaba Juhasz, M.D., Ph.D. | Pediatrics, Neurology |
| Otto Muzik, Ph.D. | Pediatrics, Radiology, Neurology |
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| Eishi Asano, M.D., Ph.D. Pediatrics, Neurology | |
| Research Interest
| The core aim of the research pursued in my laboratory is to generate functional brain atlases in four dimensions, incorporating ‘space’ as well as ‘time’, using unique intracranial electrophysiological signals in patients who undergo surgical resection of a seizure focus and/or tumor.
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| Disease/Disorder
| Epilepsy, Brain tumor.
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| Species
| Human | |
| Methods
| EEG, Intracranial electrocorticography (ECoG), Cortico-cortical evoked potentials (CCEPs), Diffusion weighted tractography, 3D-surface rendered MRI, Neuropsychological tests, Eye tracking system.
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| Key Collaborators
| Harry T. Chugani, MD, Csaba Juhasz, MD, PhD, Justin Jeong, PhD, Robert Rothermel, PhD, Sandeep Sood, MD, Noa Ofen, PhD, Otto Muzik, PhD.
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| Division/Laboratory
| Department of Neurodiagnostics (EEG lab); Epilepsy surgery program | |
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| Alan Dombkowski, Ph.D. Pediatrics | |
| Research Interest
| Under two federally funded grants we are studying molecular contributors to the epileptogenic potential of cortical tubers in tuberous sclerosis complex (TSC). We use genomic and bioinformatics technologies to characterize gene and protein expression patterns, microRNAs, mutations, and epigenetic modifications in human brain tissue resected for the treatment of intractable epilepsy. The outcomes of this research are expected to expand our understanding of epilepsy in TSC, identify novel therapeutic targets, and improve diagnostic imaging methods.
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| Disease/Disorder
| Tuberous sclerosis complex, Epilepsy.
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| Species
| Human (brain tissue, cell culture) | |
| Methods
| Next-generation sequencing, Microarrays, RT-PCR, Proteomics.
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| Key Collaborators
| Harry Chugani, Diane Chugani, Eishi Asano, Paul Stemmer.
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| Csaba Juhasz, M.D., Ph.D. Pediatrics, Neurology | |
| Research Interest
| Functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders with a particular interest in the pathophysiology and progression of Sturge-Weber Syndrome.
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| Disease/Disorder
| Epilepsy, brain tumors, sturge-weber syndrome and developmental brain disorders
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| Species
| Human. | |
| Methods
| PET imaging and EEG.
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| Otto Muzik, Ph.D. Pediatrics, Radiology, Neurology | |
| Research Interest
| PET imaging and Pediatric imaging.
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| Disease/Disorder
| Epilepsy.
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| Species
| Human. | |
| Methods
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PET | |
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