Pediatric Research
| Eishi Asano, M.D., Ph.D. | Pediatrics, Neurology |
| Vaibhav A. Diwadkar, Ph.D. | Psychiatry & Behavioral Neurosciences, Psychology |
| Alan Dombkowski, Ph.D. | Pediatrics |
| John Hannigan, Ph.D. | Obstetrics and Gynecology, Psychology |
| Joseph L. Jacobson, Ph.D. | Psychiatry & Behavioral Neurosciences |
| Sandra W. Jacobson, Ph.D. | Psychiatry & Behavioral Neurosciences |
| Csaba Juhasz, M.D., Ph.D. | Pediatrics, Neurology |
| William Lyman, M.D. | Pediatrics, Psychiatry & Behavioral Neurosciences |
| Otto Muzik, Ph.D. | Pediatrics, Radiology, Neurology |
| Noa Ofen, Ph.D. | Institute of Gerontology, Pediatrics |
| David Rosenberg, M.D. | Psychiatry & Behavioral Neurosciences |
| Jeffrey A. Stanley, Ph.D. | Psychiatry & Behavioral Neurosciences |
| Moriah Thomason, Ph.D. | Pediatrics |
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| Eishi Asano, M.D., Ph.D. Pediatrics, Neurology | |
| Research Interest
| The core aim of the research pursued in my laboratory is to generate functional brain atlases in four dimensions, incorporating ‘space’ as well as ‘time’, using unique intracranial electrophysiological signals in patients who undergo surgical resection of a seizure focus and/or tumor.
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| Disease/Disorder
| Epilepsy, Brain tumor.
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| Species
| Human | |
| Methods
| EEG, Intracranial electrocorticography (ECoG), Cortico-cortical evoked potentials (CCEPs), Diffusion weighted tractography, 3D-surface rendered MRI, Neuropsychological tests, Eye tracking system.
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| Key Collaborators
| Harry T. Chugani, MD, Csaba Juhasz, MD, PhD, Justin Jeong, PhD, Robert Rothermel, PhD, Sandeep Sood, MD, Noa Ofen, PhD, Otto Muzik, PhD.
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| Division/Laboratory
| Department of Neurodiagnostics (EEG lab); Epilepsy surgery program | |
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| Vaibhav A. Diwadkar, Ph.D. Psychiatry & Behavioral Neurosciences, Psychology | |
| Research Interest
| Using imaging to study the functional organization of cortico-striatal and cortico-limbic networks in normal development and to understand dysfunction in these circuits in vulnerable and disordered adolescent populations.
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| Disease/Disorder
| Schizophrenia and mood disorders.
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| Species
| Human | |
| Methods
| fMRI and neuropsychology tests.
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| Key Collaborators
| Jeffrey Stanley, Nash Boutros, Bob Freedman, David Rosenberg, Otto Muzik, Harry Chugani, Diane Chugani, Joseph Jacobson, Sandra Jacobson
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| Alan Dombkowski, Ph.D. Pediatrics | |
| Research Interest
| Under two federally funded grants we are studying molecular contributors to the epileptogenic potential of cortical tubers in tuberous sclerosis complex (TSC). We use genomic and bioinformatics technologies to characterize gene and protein expression patterns, microRNAs, mutations, and epigenetic modifications in human brain tissue resected for the treatment of intractable epilepsy. The outcomes of this research are expected to expand our understanding of epilepsy in TSC, identify novel therapeutic targets, and improve diagnostic imaging methods.
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| Disease/Disorder
| Tuberous sclerosis complex, Epilepsy.
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| Species
| Human (brain tissue, cell culture) | |
| Methods
| Next-generation sequencing, Microarrays, RT-PCR, Proteomics.
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| Key Collaborators
| Harry Chugani, Diane Chugani, Eishi Asano, Paul Stemmer.
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| John Hannigan, Ph.D. Obstetrics and Gynecology, Psychology | |
| Research Interest
| Neurobehavioral effects of prenatal drug and alcohol exposure.
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| Disease/Disorder
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Fetal alcohol spectrum disorder. | |
| Species
| Rats, mice and human. | |
| Methods
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MRI, MRS and fMRI. | |
| Key Collaborators
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Lisa Chiodo, Jeffrey Stanley, Viabhav Diwadkar and Scott Moffat | |
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| Joseph L. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences | |
| Research Interest
| Effects of prenatal exposure to alcohol and environmental contaminants (PCBs, mercury, lead) on infant and child development; research methods; study design.
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| Disease/Disorder
| Fetal alcohol syndrome, fetal alcohol spectrum disorder, ADHD and alcohol abuse and dependence.
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| Species
| Human. | |
| Methods
| Neuropsychological assessment, structural MRI, functional MRI and diffusion tensor imaging
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| Key Collaborators
| Sandra W. Jacobson (all studies), Christopher Molteno and Ernesta Meintjes (Cape Town neuroimaging and neurobehavioral studies), Gina Muckle (Inuit studies)
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| Sandra W. Jacobson, Ph.D. Psychiatry and Behavioral Neurosciences | |
| Research Interest
| Studying the effects of prenatal exposure to alcohol, cocaine, smoking and environmental contaminants (PCBs, mercury, lead) on infant and child development, using state-of-the-art neurobehavioral and neuroimaging outcome measures.
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| Disease/Disorder
| Fetal alcohol syndrome (FAS), fetal alcohol spectrum disorder (FASD), attention deficit hyperactivity disorder (ADHD), alcohol abuse and dependence in pregnant women and adolescents.
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| Species
| human | |
| Methods
| Eyeblink conditioning, fMRI, sMRI, DTI, infant and child neuropsychological assessment (standardized and nonstandardized tests) and alcohol and drug ascertainment and dependence.
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| Key Collaborators
| Joseph L. Jacobson (all studies), Mark Stanton (EBC), Christopher Molteno and Ernesta Meintjes (Cape Town fMRI and neurobehavioral studies), Gina Muckle (Inuit studies), Cynthia Bearer (meconium), Tim Oberlander and Joanne Weinberg (cortisol and pain reactivity), Charles Nelson (ERP)
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| Csaba Juhasz, M.D., Ph.D. Pediatrics, Neurology | |
| Research Interest
| Functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders with a particular interest in the pathophysiology and progression of Sturge-Weber Syndrome.
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| Disease/Disorder
| Epilepsy, brain tumors, sturge-weber syndrome and developmental brain disorders
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| Species
| Human. | |
| Methods
| PET imaging and EEG.
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| William Lyman, M.D. Pediatrics, Psychiatry & Behavioral Neurosciences | |
| Research Interest
| Stem cells: the good, the bad and the ugly. Good stem cells for nervous system. The bad stem cells in cancer. The ugly stem cells in kidney disease because of the dispute about whether they even exist. | |
| Disease/Disorder
| Fetal alcohol spectrum disorder, neuroblastoma, cerebral palsy, nephrotic syndrome and tubular necrosis
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| Species
| Fetal human brain, blood and kidney tissues. | |
| Methods
| Cell, tissue culture and molecular biology and functional genomics.
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| Key Collaborators
| S. Vangipuram, J. Wang, N. Choutai, G. Kapur, T. Mattoo, R. Novak, A. Dombkowski.
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| Otto Muzik, Ph.D. Pediatrics, Radiology, Neurology | |
| Research Interest
| PET imaging and Pediatric imaging.
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| Disease/Disorder
| Epilepsy.
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| Species
| Human. | |
| Methods
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PET | |
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| Noa Ofen, Ph.D. Institute of Gerontology, Pediatrics | |
| Research Interest
| The typical and atypical development of memory systems in the human brain. Functional and structural brain development. Relationship between variation in cognitive and brain development and genetic polymorphism.
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| Disease/Disorder
| Developmental disorders, prematurity and schizophrenia
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| Species
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Human | |
| Methods
| MRI, fMRI, DTI, Cognitive assessment, Genetics.
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| Key Collaborators
| Viabhav Diwadkar, Jeffrey Stanley, Naftali Raz, Joe Jacobson, Sandra Jacobson, Sarah Raz, Moriah Thomason
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| David Rosenberg, M.D. Psychiatry & Behavioral Neurosciences | |
| Research Interest
| Our lab is focused on uncovering the neurobiology of pediatric mental illness and translating those findings into advances in diagnostics and treatment.
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| Disease/Disorder
| Obsessive Compulsive Disorder, major depression, and bipolar disorder
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| Species
| Human (pediatric) | |
| Methods
| MRI, MRS, fMRI, genetics and cortisol.
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| Key Collaborators
| Jeffrey A Stanley, PhD (WSU), Paul Arnold, MD & Jim Kennedy (University of Toronto), Greg Hanna (University of Michigan)
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| Jeffrey A. Stanley, Ph.D. Psychiatry & Behavioral Neurosciences | |
| Research Interest
| To gain a greater understanding of neurodevelopmental effects of morphology, function and biochemistry on childhood disorders such as ADHD using different MR methodologies.
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| Disease/Disorder
| ADHD, schizophrenia, anxiety and mood disorders.
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| Species
| Human (pediatric) | |
| Methods
| Different MR methodologies.
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| Key Collaborators
| Vaibhav Diwadkar, John Hannigan, Mark Greenwald, Nash Boutros, Brian Martis (U. of Michigan), Jair Soares (U. of Texas at Houston)
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| Moriah Thomason, Ph.D. Pediatrics | |
| Research Interest
| Impact of the function and maturation of multiple, large-scale brain networks on the individual cognitive and emotional developmental trajectories of children. Relationship between variation in these trajectories and variation in individual brain chemistry and genetic composition. Current projects explore development of fetal neural networks and the impact of neural network development and genetic composition on pediatric anxiety.
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| Disease/Disorder
| Developmental psychopathology.
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| Species
| Human | |
| Methods
| fMRI, DTI, resting-state fMRI, endocrine and genetic techniques
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| Key Collaborators
| David Rosenberg, Noa Ofen, Douglas Barnett, Gregory Dyson, Mary Roberts
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