Addiction and Substance Abuse
| Scott Bowen, Ph.D. | Psychology, Obstetrics and Gynecology |
| Alana C. Conti, Ph.D. | Neurological Surgery / Pediatric Neurosurgery |
| Shane Perrine, Ph.D. | Psychiatry & Behavioral Neurosciences |
| Mark Greenwald, Ph.D. | Psychiatry & Behavioral Neurosciences, Psychology, Affiliated Research Faculty in Psychology |
| Christine A. Rabinak, Ph.D. | Pharmacy Practice |
| Manuel Tancer, M.D. | Psychiatry & Behavioral Neurosciences, Pharmacology |
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| Scott Bowen, Ph.D. Psychology, Obstetrics and Gynecology | |
| Research Interest
| research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.
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| Rats and mice. | |
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| Key Collaborators
| John Hannigan
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| Alana C. Conti, Ph.D. Neurological Surgery, Pediatric Neurosurgery | |
| Research Interest
| Experiments designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol in the adult and juvenile brain. Additional studies focus on behavioral outcome following ethanol exposure. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in studies related to Fetal Alcohol Syndrome. Future projects will focus on development of a novel in vitro model of Fetal Alcohol Syndrome and defining the cellular mechanisms that regulate ethanol sensitivity following traumatic brain injury using both adult and juvenile mouse models.
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Traumatic brain injury, fetal alcohol spectrum disorder and alcohol sensitivity. | |
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Mice | |
| Methods
| Molecular Biology, Immunohistochemistry, Primary Neuronal Cultures, Behavioral Animal Models.
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Don Kuhn, Scott Bowen, Tiffany mathews, Shane Perrine, John Hannigan | |
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| Shane A. Perrine, Ph.D. Psychiatry & Behavioral Neurosciences | |
| Research Interest
| Our laboratory focuses on the neuropsychopharmacology of drug addiction and co-occurring psychiatric conditions, namely depression and anxiety. The goal of my research is to elucidate the mechanisms by which drugs, particularly psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (ecstasy), affect neurochemistry and behavior. Using animal models, we seek to identify and understand the plasticity of the human brain in response to acute and repeated drug exposure, as well as, stressors and cues that lead to anxiety, depression and relapse to drug seeking. We are currently pursuing two major research studies: 1) Determine the neurochemical underpinnings that are disrupted by psychostimulants and lead to anxiety, depression and maladaptive reward behaviors; 2) Understand the neurobiological basis that underlies comorbidity of PTSD and drug abuse. | |
| Disease/Disorder
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Drug abuse and dependence, anxiety and depression | |
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Rat | |
| Methods
| Rodent models/tests for reward, anxiety, and depression related behaviors, western blotting, ELISA, HPLC, and proton-magnetic resonance spectroscopy.
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| Key Collaborators
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Matthew Galloway, Manuel Tancer, Mark Greenwald, Scott Bowen, Jeffrey Stanley, David Thomas, Donald Kuhn, Alana Conti, Pamela VandeVord, Michael Church, Bill Fantegrossi (U Arkansas), Leonard Howell (Emory U), Israel Liberzon (U Michigan), Mark Simmons (NEOUCOMP) and Ellen Unterwald (Temple U). | |
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| Mark Greenwald, Ph.D. Psychiatry & Behavioral Neurosciences, Psychology; Affiliated Research Faculty in Psychology | |
| Research Interest
| Pharmacological, environmental and individual difference determinants of drug-seeking/use behavior (primary endpoint) and neural processes (measured with in vivo imaging methods) related to these behaviors.
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| Disease/Disorder
| opioid, cocaine, marijuana, nicotine, and alcohol use disorders.
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| Human. | |
| Methods
| PET (opioid and dopamine), 1H spectroscopy, fMRI, TMS and EEG.
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| Key Collaborators
| Jon-Kar Zubieta (Univ. of Michigan: PET and fMRI), Jeffrey Stanley (1H spectroscopy), Nash Boutros (TMS), Tim Roehrs (EEG).
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| Division/Laboratory
| Human Pharmacology Laboratory in the Substance Abuse Research Division | |
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| Christine A. Rabinak, Ph.D. Pharmacy Practice | |
| Research Interest
| Behavioral and neurobiological mechanisms of fear learning and memory; cannabinoid system and emotional processing; threat perception and regulations of affect; biomarkers of development and maintenance of anxiety disorders.
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| Disease/Disorder
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Anxiety disorders, Trauma | |
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| Human | |
| Methods
| fMRI, EEG, ERP, psychopharmacology, behavio .
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| Key Collaborators
| Mark Greenwald (WSU), Jeff Stanley (WSU), K. Luan Phan (University of Illinois at Chicago), Mohammed Milad (MGH & Harvard), Greg H. Proudfit (SUNY Stony Brook).
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| Manuel Tancer, M.D. Psychiatry & Behavioral Neurosciences, Pharmacology | |
| Research Interest
| Effects of MDMA (Ecstasy) measured with fMRI and MRS.
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