Anna Moszczynska
Office Address
Pharmaceutical Sciences Department
College of Pharmacy and Health Sciences
Wayne State University
259 Mack Avenue
Detroit, MI 48201
Division
Pharmaceutical Sciences
Office Phone
313-577-1257
Research Interests
My current research focuses on discovery of novel molecular and epigenetic drug targets to attenuate methamphetamine (METH) abuse in heavy users of the drug. My primary research interest is parkin and proteasome, two components of the ubiquitin-proteasome system, as drug targets in MUD. My secondary research interest lies in transposable elements (rat LINE-1 an Identifier element) and their role in mediating METH neurotoxicity.
Research Methods
Research Models: Rat model of heavy METH use, rat models of METH neurotoxicity (chronic METH and METH overdose), rat mode of parkin deficiency (Park2-/- rats) and parkin excess (parkin overexpressing rats).
Main Research Techniques: Native and 2D gel electrophoresis/western blotting, multi-PAGE electrophoresis/western blotting, co-immunoprecipitation, immunohistochemistry and confocal microscopy, in vivo gene transfer with adeno-associated viral vectors, manipulation of protein-protein interactions with TAT-peptides, anxiety and cognitive behavioral tests, and enzymatic assays, as well as proteomic analysis.