David Rosenberg
Laboratory Web Site
Child and Adolescent Research Services
Research Interests
My main research interest has been the identification of neurobiological markers of pediatric obsessive-compulsive disorder (OCD) and related disorders. Specific research interests have included the examination of glutamate, neurochemical, functional, and structural abnormalities in pediatric OCD and obsessive-compulsive behaviors (OCB) using volumetric and functional MRI, voxel based morphometry and magnetic resonance spectroscopy and most recently combining these brain imaging methods with genetic assessment. The goal of my research is to provide a better understanding of the impact of genetic variants on fronto-striatal-thalamocortical and glutamatergic dysregulation in the pathogenesis of OCD and OCB and lead to new diagnostic, therapeutic, and prevention strategies.
Disease/Disorder
Obsessive Compulsive Disorder, major depression, and bipolar disorder
Species
Human (pediatric)
Methods
MRI, MRS, fMRI, genetics and cortisol.
Key Collaborators
Vaibhav Diwadkar, Jeffrey A Stanley, Paul Arnold & Jim Kennedy (University of Toronto), Greg Hanna (University of Michigan)