Stroke

Donald J. DeGracia, Ph.D.	Physiology
Paula Dore-Duffy, Ph.D.	Neurology
E. Mark Haacke, Ph.D.	Biomedical Engineering, Radiology
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		Donald J. DeGracia, Ph.D. Associate Professor Physiology
Research Interest	We study the mechanisms of cell death following brain ischemia and reperfusion, focusing on the causes and consequences of reperfusion-induced inhibition of protein synthesis, or translation arrest. This translation arrest appears to be part of the post-ischemic neuronal stress response. We have evaluated classical ribosome biochemistry, intracellular stress responses and most recently began investigating mRNA regulatory mechanisms, including stress granules and HuR granules. The lab is currently funded by the National Institute of Neurological Disorders and Stroke at the NIH.
Disease/Disorder	brain ischemia and reperfusion injury: stroke, cardiac arrest and resuscitation brain damage
Species	Rodents
Methods	Molecular biology.
Key Collaborators	Jose Rafols, Ph.D.
Publications	PubMed Search (past 5 years).
Division/Laboratory	Laboratory
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		Paula Dore-Duffy, Ph.D. Professor Neurology
Research Interest	The role of the microvascular pericyte in vascular function and CNS vascular diseases. The pericyte is an integral member of the blood brain barrier and neurovascular unit. As such it functions as a regulator cell and is involved in regulation of focal capillary blood flow, angiogenesis, inflammation and is now known to be a source of adult stem cells. Ongoing studies include investigation of pericytes in stem cell therapeutic paradigms in EAE and Traumatic brain injury.
Disease/Disorder	Multiple sclerosis, traumatic brain injury and stroke
Species	Rats and mice.
Methods	Immune based techniques, cell culture, molecular biology, protein chemistry, FACs analysis, imaging and translational research.
Key Collaborators	Alexander Gow, Jose Rafols, Christian Kreipke, William Brusilow and Richard Needleman, and outside the University Joseph Lamanna and Robert Miller at Case Western Reserve School of Medicine in Cleveland and Richard Milner at Scripps Research Institute and Gregory del Zoppo at the University of Washington in Seattle.
Publications	PubMed Search (past 5 years).
Division/Laboratory	Laboratory
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		E. Mark Haacke, Ph.D. Professor Biomedical Engineering, Radiology
Research Interest	We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from multiple sclerosis to dementia.
Disease/Disorder	Stroke, trauma, cancer, multiple sclerosis and aging.
Species	Human, rats and mice.
Methods	MRI
Key Collaborators	Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern
Publications	PubMed Search (past 5 years).
Division/Laboratory	MR Research Facility
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