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Prenatal Exposure Research

Scott Bowen, Ph.D.	Psychology, Obstetrics and Gynecology
Alana C. Conti, Ph.D.	Neurological Surgery/Pediatric Neurosurgery
Matthew P. Galloway, Ph.D.	Psychiatry & Behavioral Neurosciences, Anesthesiology
John Hannigan, Ph.D.	Obstetrics and Gynecology, Psychology
Joseph L. Jacobson, Ph.D.	Psychiatry & Behavioral Neurosciences
Sandra W. Jacobson, Ph.D.	Psychiatry & Behavioral Neurosciences
William Lyman, M.D.	Pediatrics, Psychiatry & Behavioral Neurosciences
Noa Ofen, Ph.D.	Institute of Gerontology, Pediatrics
Moriah Thomason, Ph.D.	Pediatrics
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		Scott Bowen, Ph.D. Associate Professor Psychology, Obstetrics and Gynecology
Research Interest	research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.
Disease/Disorder
Species	Rats and mice.
Methods
Key Collaborators	John Hannigan
Publications	PubMed Search (past 5 years).
Division/Laboratory	Behavioral Pharmacology and Toxicology Laboratory
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		Alana C. Conti, Ph.D. Assistant Professor Neurological Surgery, Pediatric Neurosurgery
Research Interest	Experiments designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol in the adult and juvenile brain. Additional studies focus on behavioral outcome following ethanol exposure. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in studies related to Fetal Alcohol Syndrome. Future projects will focus on development of a novel in vitro model of Fetal Alcohol Syndrome and defining the cellular mechanisms that regulate ethanol sensitivity following traumatic brain injury using both adult and juvenile mouse models.
Disease/Disorder	Traumatic brain injury, fetal alcohol spectrum disorder and alcohol sensitivity.
Species	Mice
Methods	Molecular Biology, Immunohistochemistry, Primary Neuronal Cultures, Behavioral Animal Models.
Key Collaborators	Don Kuhn, Scott Bowen, Tiffany mathews, Shane Perrine, John Hannigan
Publications	PubMed Search (past 5 years).
Division/Laboratory	Laboratory
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		Matthew P. Galloway, Ph.D. Professor Psychiatry & Behavioral Neurosciences, Anesthesiology
Research Interest	Neurochemical pharmacology of 1H-MRS.
Disease/Disorder
Species	Rats and mice.
Methods
Key Collaborators
Publications	PubMed Search (past 5 years).
Division/Laboratory	Molecular Neuroimaging Laboratory
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		John Hannigan, Ph.D. Professor Obstetrics and Gynecology, Psychology
Research Interest	Neurobehavioral effects of prenatal drug and alcohol exposure.
Disease/Disorder	Fetal alcohol spectrum disorder.
Species	Rats, mice and human.
Methods	MRI, MRS and fMRI.
Key Collaborators	Lisa Chiodo, Jeffrey Stanley, Viabhav Diwadkar and Scott Moffat
Publications	PubMed Search (past 5 years).
Division/Laboratory	Neurobehavioral Teratology Laboratory
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		Joseph L. Jacobson, Ph.D. Professor Psychiatry & Behavioral Neurosciences
Research Interest	Effects of prenatal exposure to alcohol and environmental contaminants (PCBs, mercury, lead) on infant and child development; research methods; study design.
Disease/Disorder	Fetal alcohol syndrome, fetal alcohol spectrum disorder, ADHD and alcohol abuse and dependence.
Species	Human.
Methods	Neuropsychological assessment, structural MRI, functional MRI and diffusion tensor imaging
Key Collaborators	Sandra W. Jacobson (all studies), Christopher Molteno and Ernesta Meintjes (Cape Town neuroimaging and neurobehavioral studies), Gina Muckle (Inuit studies)
Publications	PubMed Search (past 5 years).
Division/Laboratory
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		Sandra W. Jacobson, Ph.D. Professor Psychiatry and Behavioral Neurosciences
Research Interest	Studying the effects of prenatal exposure to alcohol, cocaine, smoking and environmental contaminants (PCBs, mercury, lead) on infant and child development, using state-of-the-art neurobehavioral and neuroimaging outcome measures.
Disease/Disorder	Fetal alcohol syndrome (FAS), fetal alcohol spectrum disorder (FASD), attention deficit hyperactivity disorder (ADHD), alcohol abuse and dependence in pregnant women and adolescents.
Species	human
Methods	Eyeblink conditioning, fMRI, sMRI, DTI, infant and child neuropsychological assessment (standardized and nonstandardized tests) and alcohol and drug ascertainment and dependence.
Key Collaborators	Joseph L. Jacobson (all studies), Mark Stanton (EBC), Christopher Molteno and Ernesta Meintjes (Cape Town fMRI and neurobehavioral studies), Gina Muckle (Inuit studies), Cynthia Bearer (meconium), Tim Oberlander and Joanne Weinberg (cortisol and pain reactivity), Charles Nelson (ERP)
Publications	PubMed Search (past 5 years).
Division/Laboratory	Child Development Research Laboratory
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		William Lyman, M.D. Professor Pediatrics, Psychiatry & Behavioral Neurosciences
Research Interest	Stem cells: the good, the bad and the ugly. Good stem cells for nervous system. The bad stem cells in cancer. The ugly stem cells in kidney disease because of the dispute about whether they even exist.
Disease/Disorder	Fetal alcohol spectrum disorder, neuroblastoma, cerebral palsy, nephrotic syndrome and tubular necrosis
Species	Fetal human brain, blood and kidney tissues.
Methods	Cell, tissue culture and molecular biology and functional genomics.
Key Collaborators	S. Vangipuram, J. Wang, N. Choutai, G. Kapur, T. Mattoo, R. Novak, A. Dombkowski.
Publications	PubMed Search (past 5 years).
Division/Laboratory	Children’s Research Center of Michigan
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		Noa Ofen, Ph.D. Assistant Professor Institute of Gerontology, Pediatrics
Research Interest	The typical and atypical development of memory systems in the human brain. Functional and structural brain development. Relationship between variation in cognitive and brain development and genetic polymorphism.
Disease/Disorder	Developmental disorders, prematurity and schizophrenia
Species	Human
Methods	MRI, fMRI, DTI, Cognitive assessment, Genetics.
Key Collaborators	Viabhav Diwadkar, Jeffrey Stanley, Naftali Raz, Joe Jacobson, Sandra Jacobson, Sarah Raz, Moriah Thomason
Publications	PubMed Search (past 5 years).
Division/Laboratory	Ofen Lab
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		Moriah Thomason, Ph.D. Assistant Professor Pediatrics
Research Interest	Impact of the function and maturation of multiple, large-scale brain networks on the individual cognitive and emotional developmental trajectories of children. Relationship between variation in these trajectories and variation in individual brain chemistry and genetic composition. Current projects explore development of fetal neural networks and the impact of neural network development and genetic composition on pediatric anxiety.
Disease/Disorder	Developmental psychopathology.
Species	Human
Methods	fMRI, DTI, resting-state fMRI, endocrine and genetic techniques
Key Collaborators	David Rosenberg, Noa Ofen, Douglas Barnett, Gregory Dyson, Mary Roberts
Publications	PubMed Search (past 5 years).
Division/Laboratory	Developmental Neuroscience Lab
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