Neuropharmacology
| Scott Bowen, Ph.D. | Psychology, Obstetrics and Gynecology |
| Mark Greenwald, Ph.D. | Psychiatry & Behavioral Neurosciences, Affiliated Research Faculty in Psychology |
| Donald M. Kuhn, Ph.D. | Psychiatry & Behavioral Neurosciences |
| Shane A. Perrine, Ph.D. | Psychiatry & Behavioral Neurosciences |
| Manuel Tancer, M.D. | Psychiatry & Behavioral Neurosciences, Pharmacology |
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| Scott Bowen, Ph.D. Psychology, Obstetrics and Gynecology | |
| Research Interest
| research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.
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| Species
| Rats and mice. | |
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| Key Collaborators
| John Hannigan
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| Mark Greenwald, Ph.D. Psychiatry & Behavioral Neurosciences, Psychology; Affiliated Research Faculty in Psychology | |
| Research Interest
| Pharmacological, environmental and individual difference determinants of drug-seeking/use behavior (primary endpoint) and neural processes (measured with in vivo imaging methods) related to these behaviors.
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| Disease/Disorder
| opioid, cocaine, marijuana, nicotine, and alcohol use disorders.
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| Species
| Human. | |
| Methods
| PET (opioid and dopamine), 1H spectroscopy, fMRI, TMS and EEG.
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| Key Collaborators
| Jon-Kar Zubieta (Univ. of Michigan: PET and fMRI), Jeffrey Stanley (1H spectroscopy), Nash Boutros (TMS), Tim Roehrs (EEG).
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| Division/Laboratory
| Human Pharmacology Laboratory in the Substance Abuse Research Division | |
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| Donald M. Kuhn, Ph.D. Psychiatry & Behavioral Neurosciences | |
| Research Interest
| We are interested in the role of non-neuronal cells in contributing to brain damage caused by drugs, disease and injury. We are also interested in the physiological and neurochemical roles played serotonin as determined through studies with a knockout mouse lacking brain serotonin (i.e., TPH2 knockout).
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| Disease/Disorder
| traumatic brain injury, parkinson’s disease, depression and OCD
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| Species
| Mice, brain tissue and bacteria. | |
| Methods
| Neurochemistry, biochemistry, pharmacology, molecular biology, transgenic and knockout mouse models of CNS diseases
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| Key Collaborators
| Mariana Angoa-Perez, Michael Kane, David M. Thomas, Christian W. Kreipke, Alana Conti, Matthew Galloway, Shane Perrine
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| Shane A. Perrine, Ph.D. Psychiatry & Behavioral Neurosciences | |
| Research Interest
| Our laboratory focuses on the neuropsychopharmacology of drug addiction and co-occurring psychiatric conditions, namely depression and anxiety. The goal of my research is to elucidate the mechanisms by which drugs, particularly psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (ecstasy), affect neurochemistry and behavior. Using animal models, we seek to identify and understand the plasticity of the human brain in response to acute and repeated drug exposure, as well as, stressors and cues that lead to anxiety, depression and relapse to drug seeking. We are currently pursuing two major research studies: 1) Determine the neurochemical underpinnings that are disrupted by psychostimulants and lead to anxiety, depression and maladaptive reward behaviors; 2) Understand the neurobiological basis that underlies comorbidity of PTSD and drug abuse. | |
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Drug abuse and dependence, anxiety and depression | |
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Rat | |
| Methods
| Rodent models/tests for reward, anxiety, and depression related behaviors, western blotting, ELISA, HPLC, and proton-magnetic resonance spectroscopy.
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| Key Collaborators
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Matthew Galloway, Manuel Tancer, Mark Greenwald, Scott Bowen, Jeffrey Stanley, David Thomas, Donald Kuhn, Alana Conti, Pamela VandeVord, Michael Church, Bill Fantegrossi (U Arkansas), Leonard Howell (Emory U), Israel Liberzon (U Michigan), Mark Simmons (NEOUCOMP) and Ellen Unterwald (Temple U). | |
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| Manuel Tancer, M.D. Psychiatry & Behavioral Neurosciences, Pharmacology | |
| Research Interest
| Effects of MDMA (Ecstasy) measured with fMRI and MRS.
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