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Multiple Sclerosis and White Matter Disorders

Joyce Benjamins, Ph.D	Neurology, Biochemistry, Immunology, Microbiology
Paula Dore-Duffy, Ph.D.	Neurology
Alexander Gow, Ph.D.	Center for Molecular Medicine and Genetics
E. Mark Haacke, Ph.D.	Biomedical Engineering, Radiology
Jiani Hu, Ph.D.	Radiology
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		Joyce Benjamins, Ph.D. Professor and Associate Chair for Research Neurology
Research Interest	Research interests include regulation of myelination, glial differentiation, and the roles of metabotropic glutamate receptors and the kynurenine pathway in mediating oligodendroglial injury. One current project investigates the effects of glutamate receptor agonists and antagonists on disease outcome in EAE, an animal model of multiple sclerosis. A collaboration with Dr. Lisak utilizes gene arrays to investigate the effects of cytokines on gene expression in CNS neurons and glia.
Disease/Disorder	Diseases affecting myelin, including multiple sclerosis, genetic disorders and neurodegenerative disorders.
Species	Rats and mice.
Methods	Western blotting, PCR, gene array analysis and immunocytochemistry.
Key Collaborators	Robert Lisak and John Kamholz
Publications	PubMed Search (past 5 years).
Division/Laboratory	Laboratory
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		Paula Dore-Duffy, Ph.D. Professor Neurology
Research Interest	The role of the microvascular pericyte in vascular function and CNS vascular diseases. The pericyte is an integral member of the blood brain barrier and neurovascular unit. As such it functions as a regulator cell and is involved in regulation of focal capillary blood flow, angiogenesis, inflammation and is now known to be a source of adult stem cells. Ongoing studies include investigation of pericytes in stem cell therapeutic paradigms in EAE and Traumatic brain injury.
Disease/Disorder	Multiple sclerosis, traumatic brain injury and stroke
Species	Rats and mice.
Methods	Immune based techniques, cell culture, molecular biology, protein chemistry, FACs analysis, imaging and translational research.
Key Collaborators	Alexander Gow, Jose Rafols, Christian Kreipke, William Brusilow and Richard Needleman, and outside the University Joseph Lamanna and Robert Miller at Case Western Reserve School of Medicine in Cleveland and Richard Milner at Scripps Research Institute and Gregory del Zoppo at the University of Washington in Seattle.
Publications	PubMed Search (past 5 years).
Division/Laboratory	Laboratory
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		Alexander Gow, Ph.D. Professor Center for Molecular Medicine and Genetics, Pediatrics, Neurology
Research Interest	White matter disease and relevance to cognitive deficits.
Disease/Disorder	Depression, multiple sclerosis, Pelizaeus-Merzbacher, Auditory Processing Disorder.
Species	Mouse and Human
Methods	Knockout and transgenic mice, confocal and electron microscopy, psychoacoustics, behavior, MRI ad MRS, biochemistry, microarrays, computational modeling, drug testing to ameliorate neurodegeneration.
Key Collaborators	Robert Skoff, Anatomy and Cell Biology (WSU); Zhengqing Hu, Otolaryngology (WSU); Paula Dore-Duffy, Neurology (WSU); Jeff Stanley, Psychiatry (WSU); Shane Perrine, Psychiatry (WSU); Matthew Galloway, Psychiatry (WSU); Mark Cheng, Electrical Engineering (WSU)
Publications	PubMed Search (past 5 years).
Division/Laboratory	Laboratory of Molecular and Cellular Neuroscience
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		E. Mark Haacke, Ph.D. Professor Biomedical Engineering, Radiology
Research Interest	We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from multiple sclerosis to dementia.
Disease/Disorder	Stroke, trauma, cancer, multiple sclerosis and aging.
Species	Human, rats and mice.
Methods	MRI
Key Collaborators	Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern
Publications	PubMed Search (past 5 years).
Division/Laboratory	MR Research Facility
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		Jiani Hu, Ph.D. Associate Professor Radiology
Research Interest	Exploring in vivo MR properties of lesions for diagnosis, prognosis and treatment follow-up using the state-of-art in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques.
Disease/Disorder	Neurological disorders and cancers.
Species	Human and small animals.
Methods	MRI and MRS.
Key Collaborators	Mark Haacke
Publications	PubMed Search (past 5 years).
Division/Laboratory	MR Research Facility
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