School of Medicine

Division/Laboratory

MPSI Profile View

Cynthia Arfken, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Interested in the fields of substance abuse health services and emerging trends with part of my efforts reserved as epidemiologist and biostatistician for the division. My expertise includes biostatistics, epidemiology and health services.

Disease/Disorder

Behavioral Health

Species

Human

Methods

Research design and statistics.

Key Collaborators

Alireza Amirsadri and Mark Greenwald

Research Connect

Publications

Division/Laboratory

PubMed Search (past 5 years)

		Eishi Asano, M.D., Ph.D. Professor Pediatrics; Neurology
Research Interest	The core aim of the research pursued in my laboratory is to generate functional brain atlases in four dimensions, incorporating 'space' as well as 'time', using unique intracranial electrophysiological signals in patients who undergo surgical resection of a seizure focus and/or tumor.
Disease/Disorder	Epilepsy and brain tumor.
Species	Human
Methods	EEG, Intracranial electrocorticography (ECoG), Cortico-cortical evoked potentials (CCEPs), Diffusion weighted tractography, 3D-surface rendered MRI, Neuropsychological tests, Eye tracking system.
Key Collaborators	Harry T. Chugani, MD, Csaba Juhasz, MD, PhD, Justin Jeong, PhD, Robert Rothermel, PhD, Sandeep Sood, MD, Noa Ofen, PhD, Otto Muzik, PhD.
Research Connect
Publications	PubMed Search (past 5 years).
Division/Laboratory	Department of Neurodiagnostics (EEG lab); Epilepsy surgery program
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Mohammad R.N. Avanaki, Ph.D
Assistant Professor

Biomedical Engineering; Neurology

Research Interest

Development of new imaging modalities (optical and photoacoustic) to explore hemorrhage and tumor in neonatal brain, image analysis, resting-state functional connectivity, and molecular imaging in the brain.

Disease/Disorder

Hemorrhage and brain tumor

Species

Mice, rats, sheep and pigs.

Methods

Optical Coherence Tomography, Ultrasound and Photoacoustic Imaging.

Key Collaborators

Juri Gelovani, Sandeep Metal and Eishi Asano

Google Scholar

Publications

Division/Laboratory

Optical & Photoacoustic Imaging Research and Analysis Laboratory

Joyce Benjamins, Ph.D.
Professor and Associate Chair for Research

Neurology

Research Interest

Research interests include regulation of myelination, glial differentiation, and the roles of metabotropic glutamate receptors and the kynurenine pathway in mediating oligodendroglial injury. One current project investigates the effects of glutamate receptor agonists and antagonists on disease outcome in EAE, an animal model of multiple sclerosis. A collaboration with Dr. Lisak utilizes gene arrays to investigate the effects of cytokines on gene expression in CNS neurons and glia.

Disease/Disorder

Diseases affecting myelin, including multiple sclerosis, genetic disorders and neurodegenerative disorders.

Species

Rats and mice.

Methods

Western blotting, PCR, gene array analysis and immunocytochemistry.

Key Collaborators

Robert Lisak and John Kamholz

Research Connect

Publications

Division/Laboratory

Neurology Profile View

Bruce Berkowitz, Ph.D.
Professor

Anatomy & Cell Biology; Ophthalmology

Research Interest

Our goal is to prevent vision loss and blindness due to diabetic retinopathy and neurodegenerative disease. We develop and apply functional MRI methods to detect the effectiveness of a treatment earlier in the course of disease than is currently possible.

Disease/Disorder

Diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration and retinitis pigmentosa

Species

Human, rats and mice.

Methods

Manganese-Enhanced MRI (MEMRI).

Key Collaborators

Tim Kern (Case Western Reserve University), Paul Tofts (Brighton and Sussex Medical School, England)

Research Connect

Publications

Division/Laboratory

Laboratory

George Borszcz, Ph.D.
Associate Professor

Psychology

Research Interest

Neurobiology of emotion and pain affect; fore-brain circuitry that governs individuals' innate emotional reaction to threatening/painful stimuli; evaluation of how plasticity within this forebrain circuit results in development of depression and anxiety.

Disease/Disorder

Neurobiology of emotion, particularly the emotional response to pain.

Species

Rats

Methods

Brain stimulation, electrophysiological recording, HPLC, histological staining and immunohistochemistry.

Key Collaborators

Research Connect

Publications

Affective Neuroscience Laboratory

Division/Laboratory

Scott Bowen, Ph.D.
Associate Professor

Psychology

Research Interest

Research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.

Disease/Disorder

Behavioral pharmacology and toxicology of commonly abused drugs.

Species

Rats and mice.

Methods

Rodent models/tests for anxiety or depression behaviors, activity, memory, operant methods of reinforcement, and developmental milestones.

Key Collaborators

John Hannigan, Shane Perrine, Alana Conti, Susanne Brummelte, George Borszcz, Matthew Galloway.

Research Connect

Publications

Behavioral Pharmacology and Toxicology Laboratory

Division/Laboratory

Susanne Brummelte, Ph.D.
Assistant Professor

Psychology

Research Interest

Developmental Neuroscience, Neuroendocrinology, Behavioral Neuroscience.
My current research focuses on the effects of early adverse life experience on brain development and the subsequent behavioral and neuroanatomical changes in both, males and females. I am particularly interested in the consequences of exposure to depression, antidepression medication, stress or glucocorticoids and pain during the prenatal or postnatal period.

Disease/Disorder

(maternal) depression, stress, pain

Species

Rats

Methods

Behavioral testing, immunohistochemistry, western blotting, ELISAs etc.

Key Collaborators

Shane Perrine, Scott Bowen, George Borszcz, Carolyn Herrington

Research Connect

Publications

Developmental Psychobiology Lab

Division/Laboratory

Paul R. Burghardt, Ph.D.
Assistant Professor

Nutrition & Food Science

Research Interest

To understand how metabolism reciprocally intermingles with brain function to influence behavior.

Disease/Disorder

Obesity, prediabetes, depression.

Species

Human and rat.

Methods

PET, MRI, in situ hybridization, immunohistochemistry, ELISA, RIA.

Key Collaborators

Jeffrey Stanley

Research Connect

Publications

Division/Laboratory

Creme Laboratory

Leon Carlock, Ph.D.
Associate Professor

Center for Molecular Medicine and Genetics; Anatomy & Cell Biology

Research Interest

Cell Based Assays for cell stress and death, Entrepreneurship, Technology development and Translational Research.

Disease/Disorder

Oncology

Species

Human cells.

Methods

Novel technology based upon ribosomal translational activity in normal and stressed/dying cells

Key Collaborators

Research Connect

Publications

Center for Molecular Medicine and Genetics

Division/Laboratory

Alana C. Conti, Ph.D.
Assistant Professor

Neurological Surgery; Pediatric Neurosurgery

Research Interest

Experiments designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol in the adult and juvenile brain. Additional studies focus on behavioral outcome following ethanol exposure. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in studies related to Fetal Alcohol Syndrome. Future projects will focus on development of a novel in vitro model of Fetal Alcohol Syndrome and defining the cellular mechanisms that regulate ethanol sensitivity following traumatic brain injury using both adult and juvenile mouse models.

Disease/Disorder

Traumatic brain injury, fetal alcohol spectrum disorder and alcohol sensitivity.

Species

Mice

Methods

Molecular Biology, Immunohistochemistry, Primary Neuronal Cultures, Behavioral Animal Models.

Key Collaborators

Don Kuhn, Scott Bowen, Tiffany mathews, Shane Perrine, John Hannigan

Research Connect

Publications

Division/Laboratory

Conti Lab

Jessica S. Damoiseaux, Ph.D.
Assistant Professor

Psychology; Institute of Gerontology

Research Interest

Changes in functional and structural brain connectivity in normal and abnormal aging, with a specific focus on the early detection of Alzheimer's disease.

Disease/Disorder

Healthy aging and Alzheimer's disease.

Species

Human

Methods

functional MRI; diffusion MRI; neuropsychological assessment.

Key Collaborators

Serge Rombouts and Jeroen van der Grond, Leiden Institute for Brain and Cognition, the Netherlands.

Research Connect

Publications

Division/Laboratory

Connect Lab

Ana M. Daugherty, Ph.D.
Assistant Professor

Psychology; Psychiatry and Behavioral Neurosciences; Institute of Gerontology

Research Interest

Progressive and cumulative declines in brain structure and function are a hallmark of aging, and in greater severity constitute neurodegenerative disease, such as Alzheimer's disease and dementia. My current research evaluates possible MRI biomarkers of impending cognitive decline, as well as metabolic and vascular health risk factors (e.g., hypertension) and protective lifestyle behaviors (e.g., aerobic exercise) that modify human aging trajectories.

Disease/Disorder

Brain structure and function in aging.

Species

Human

Methods

Structural MRI; fMRI; neuropsychological testing; cardiovascular health assessment.

Key Collaborators

Research Connect

Publications

Division/Laboratory

Faculty Profile

Donald J. DeGracia, Ph.D.
Associate Professor

Physiology

Research Interest

We study the mechanisms of cell death following brain ischemia and reperfusion, focusing on the causes and consequences of reperfusion-induced inhibition of protein synthesis, or translation arrest. This translation arrest appears to be part of the post-ischemic neuronal stress response. We have evaluated classical ribosome biochemistry, intracellular stress responses and most recently began investigating mRNA regulatory mechanisms, including stress granules and HuR granules. The lab is currently funded by the National Institute of Neurological Disorders and Stroke at the NIH.

Disease/Disorder

Brain ischemia and reperfusion injury: stroke, cardiac arrest and resuscitation brain damage.

Species

Rodents

Methods

Molecular biology.

Key Collaborators

Jose Rafols, Ph.D.

Research Connect

Publications

Division/Laboratory

Degracia Laboratory

Vaibhav A. Diwadkar, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences; Psychology

Research Interest

Using imaging to study the functional organization of cortico-striatal and cortico-limbic networks in normal development and to understand dysfunction in these circuits in vulnerable and disordered adolescent populations.

Disease/Disorder

Schizophrenia and mood disorders.

Species

Human

Methods

fMRI and neuropsychology tests.

Key Collaborators

Jeffrey Stanley, Nash Boutros, Bob Freedman, David Rosenberg, Otto Muzik, Harry Chugani, Diane Chugani, Joseph Jacobson, Sandra Jacobson

Research Connect

Publications

Brain Imaging Research Division

Division/Laboratory

Alan Dombkowski, Ph.D.
Assistant Professor

Pediatrics

Research Interest

Under two federally funded grants we are studying molecular contributors to the epileptogenic potential of cortical tubers in tuberous sclerosis complex (TSC). We use genomic and bioinformatics technologies to characterize gene and protein expression patterns, microRNAs, mutations, and epigenetic modifications in human brain tissue resected for the treatment of intractable epilepsy. The outcomes of this research are expected to expand our understanding of epilepsy in TSC, identify novel therapeutic targets, and improve diagnostic imaging methods.

Disease/Disorder

Tuberous sclerosis complex, Epilepsy.

Species

Human (brain tissue, cell culture)

Methods

Next-generation sequencing, Microarrays, RT-PCR, Proteomics.

Key Collaborators

Harry Chugani, Diane Chugani, Eishi Asano, Paul Stemmer.

Research Connect

Publications

Division/Laboratory

TSCgenomics.org

Paula Dore-Duffy, Ph.D.
Professor

Neurology

Research Interest

The role of the microvascular pericyte in vascular function and CNS vascular diseases. The pericyte is an integral member of the blood brain barrier and neurovascular unit. As such it functions as a regulator cell and is involved in regulation of focal capillary blood flow, angiogenesis, inflammation and is now known to be a source of adult stem cells. Ongoing studies include investigation of pericytes in stem cell therapeutic paradigms in EAE and Traumatic brain injury.

Disease/Disorder

Multiple sclerosis, traumatic brain injury and stroke

Species

Rats and mice.

Methods

Immune based techniques, cell culture, molecular biology, protein chemistry, FACs analysis, imaging and translational research.

Key Collaborators

Alexander Gow, Jose Rafols, Christian Kreipke, William Brusilow and Richard Needleman, and outside the University Joseph Lamanna and Robert Miller at Case Western Reserve School of Medicine in Cleveland and Richard Milner at Scripps Research Institute and Gregory del Zoppo at the University of Washington in Seattle.

Research Connect

Publications

Division/Laboratory

Neurology Profile View

		Nora Fritz, PhD, PT, DPT, NCS Assistant Professor Pharmacy & Health Science (Physical Therapy); Neurology
Research Interest	Our lab examines the influence of cognition on mobility and explores exercise interventions to improve function in individuals with neurologic conditions. We are particularly interested in linking clinically observable function to structural imaging and predicting the outcomes of exercise interventions using neuroimaging.
Disease/Disorder	Neurodegenerative diseases including Multiple Sclerosis and Huntington's disease.
Species	Human
Methods	MRI, 3D motion capture, quantitative strength and sensory testing, neuropsychological testing.
Key Collaborators	Kathy Zackowski (Johns Hopkins University); Anne Kloos and Deb Kegelmeyer (The Ohio State University); Lori Quinn (Teacher's College, Columbia University).
Research Connect
Publications	PubMed Search (past 5 years).
Division/Laboratory	Neuroimaging and Neurorehabilitation Laboratory (NNL)
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Alexander Gow, Ph.D.
Professor

Center for Molecular Medicine and Genetics; Pediatrics; Neurology

Charles H. Gershenson Distinguished Fellow

Associate Director, Center for Molecular Medicine and Genetics

Research Interest

White matter disease and relevance to cognitive deficits.

Disease/Disorder

Depression, multiple sclerosis, Pelizaeus-Merzbacher, Auditory Processing Disorder

Species

Mouse and Human

Methods

Knockout and transgenic mice, confocal and electron microscopy, psychoacoustics, behavior, MRI ad MRS, biochemistry, microarrays, computational modeling, drug testing to ameliorate neurodegeneration

Key Collaborators

Robert Skoff, Anatomy and Cell Biology (WSU); Zhengqing Hu, Otolaryngology (WSU); Paula Dore-Duffy, Neurology (WSU); Jeff Stanley, Psychiatry (WSU); Shane Perrine, Psychiatry (WSU); Matthew Galloway, Psychiatry (WSU); Greg Auner, Biomedical Engineering (WSU)

Research Connect

Publications

Center for Molecular Medicine and Genetics

Division/Laboratory

James Granneman, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences; Pathology

Research Interest

Adipose tissue remodeling, molecular mechanisms of lipolysis in fat and muscle, drug target discovery.

Disease/Disorder

Diabetes and obesity.

Species

Mice.

Methods

Confocal microscopy, live cell protein-protein interaction assays, molecular biology, cell biology and high throughput compound screening

Key Collaborators

HP Moore, Ryan Thummel, Mark Cheng, Guangzhao Mao

Research Connect

Publications

Center for Integrative Metabolic and Endocrine Research (CIMER)

Division/Laboratory

Mark Greenwald, Ph.D.
Professor and Associate Chair-Research

Psychiatry & Behavioral Neurosciences; Psychology

Research Interest

Pharmacological, environmental and individual difference determinants of drug-seeking/use behavior (primary endpoint) and neural processes (measured with in vivo imaging methods) related to these behaviors.

Disease/Disorder

Opioid, cocaine, marijuana, nicotine, and alcohol use disorders.

Species

Human

Methods

PET (opioid and dopamine), 1H spectroscopy, fMRI and EEG.

Key Collaborators

Leslie Lundahl, David Ledgerwood and Cynthia Arfken (substance use disorders, HIV/AIDS); Jeffrey Stanley (1H spectroscopy); Vaibhav Diwadkar (fMRI, learning/memory); Sylvie Naar-King and Paul Burghardt (stress, physical activity and obesity); Terrance Albrecht, Ann Schwartz and Jennifer Beebe-Dimmer (KCI: chemotherapy-induced peripheral neuropathy); Timothy Roehrs (Henry Ford: EEG, sleep, pain); Margit Burmeister (Univ. of Michigan: pharmacogenetics).

Research Connect

Publications

Substance Abuse Research Division

Division/Laboratory

E. Mark Haacke, Ph.D.
Professor

Biomedical Engineering; Radiology

Research Interest

We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from Multiple Sclerosis to dementia.

Disease/Disorder

Stroke, trauma, cancer, multiple sclerosis and aging.

Species

Human, rats and mice.

Methods

MRI

Key Collaborators

Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern

Research Connect

Publications

Division/Laboratory

MR Research Facility

John Hannigan, Ph.D.
Professor

Obstetrics and Gynecology; Psychology

Research Interest

Neurobehavioral effects of prenatal drug and alcohol exposure.

Disease/Disorder

Fetal alcohol spectrum disorder.

Species

Rats, mice and human.

Methods

MRI, MRS and fMRI.

Key Collaborators

Lisa Chiodo, Jeffrey Stanley, Viabhav Diwadkar and Scott Moffat

Research Connect

Publications

Division/Laboratory

MPSI Profile View

Carolyn Harris, Ph.D.
Assistant Professor

Chemical Engineering; Neurosurgery

Research Interest

The Harris laboratory studies hydrocephalus with a prudent focus on bioengineering strategies that could improve treatment. The lab also plays a critical role in quantifying the cellular response to brain injury.

Disease/Disorder

Hydrocephalus, brain injury.

Species

Human

Methods

Key Collaborators

Research Connect

Publications

Division/Laboratory

Neurosurgy Profile

Jiani Hu, Ph.D.
Associate Professor

Radiology

Research Interest

Exploring in vivo MR properties of lesions for diagnosis, prognosis and treatment follow-up using the state-of-art in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques.

Disease/Disorder

Neurological disorders and cancers.

Species

Human and small animals.

Methods

MRI and MRS.

Key Collaborators

Mark Haacke

Research Connect

Publications

Division/Laboratory

MR Research Facility

Joseph L. Jacobson, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Effects of prenatal exposure to alcohol and environmental contaminants (PCBs, mercury, lead) on infant and child development; research methods; study design.

Disease/Disorder

Fetal alcohol syndrome, fetal alcohol spectrum disorder, ADHD and alcohol abuse and dependence.

Species

Human.

Methods

Neuropsychological assessment, structural MRI, functional MRI and diffusion tensor imaging.

Key Collaborators

Sandra W. Jacobson (all studies), Christopher Molteno and Ernesta Meintjes (Cape Town neuroimaging and neurobehavioral studies), Gina Muckle (Inuit studies).

Research Connect

Publications

Division/Laboratory

Child Development

Sandra W. Jacobson, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Studying the effects of prenatal exposure to alcohol, cocaine, smoking and environmental contaminants (PCBs, mercury, lead) on infant and child development, using state-of-the-art neurobehavioral and neuroimaging outcome measures.

Disease/Disorder

Fetal alcohol syndrome (FAS), fetal alcohol spectrum disorder (FASD), attention deficit hyperactivity disorder (ADHD), alcohol abuse and dependence in pregnant women and adolescents.

Species

Human

Methods

Eyeblink conditioning, fMRI, sMRI, DTI, infant and child neuropsychological assessment (standardized and nonstandardized tests) and alcohol and drug ascertainment and dependence.

Key Collaborators

Joseph L. Jacobson (all studies), Mark Stanton (EBC), Christopher Molteno and Ernesta Meintjes (Cape Town fMRI and neurobehavioral studies), Gina Muckle (Inuit studies), Cynthia Bearer (meconium), Tim Oberlander and Joanne Weinberg (cortisol and pain reactivity), Charles Nelson (ERP).

Research Connect

Publications

Division/Laboratory

Child Development

Arash Javanbakht, M.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Neurobiology of cognitive (e.g. personal interpretation of the event), cultural, physical, and temporal context in development of negative effects of trauma and PTSD. I am also interested in use of virtual reality and other technological advances in combination with psychotherapy and medications in treatment of GAD, phobias, and PTSD.

Disease/Disorder

GAD, Phobias, PTSD, Depression

Species

Human

Methods

Skin Conductance, fMRI, Genetics, Cortisol.

Key Collaborators

Vaibhav Diwadkar, David Rosenberg, Alireza Amirsadri, Cynthia Arfken, Shane Perrine, Israel Liberzon (UofM).

Research Connect

Publications

Stress, Trauma, and Anxiety Research and Clinical Program

Division/Laboratory

Justin Jeongwon Jeong, Ph.D.
Assistant Professor

Pediatrics; Neurology

Research Interest

My background and the focus of my research primarily involve development of advanced Magnetic Resonance Imaging (MRI) techniques and application of this technology to pediatric neurological disorders such as epilepsy and developmental delay.

Disease/Disorder

Epilepsy, Cognitive/Language/Motor/Behavioral developmental delay, Autisms and Sturge-Weber Syndrome.

Species

Human

Methods

DTI tractography connectome, Intracranial electrocorticography, PET and fMRI.

Key Collaborators

Eishi Asano, Csaba Juhasz, Sidhartha Tan, Michael E. Behen, Harry T. Chugani

Research Connect

Publications

Positron Emission Tomography (PET) Center

Division/Laboratory

Quan Jiang, Ph.D
Professor

Neurology

Research Interest

I am interested in the development of new MRI methodologies and its applications related to neurological diseases.

Disease/Disorder

Stroke, Traumatic Brain Injury, diabetes and other neurological diseases.

Species

Human, rats and mice.

Methods

MRI (DTI, fMRI, DCE and DSC MRI etc).

Key Collaborators

Drs. Zhengang Zhang, Li Zhang, Jiani Hu, and Michael Chopp

Research Connect

Publications

Division/Laboratory

Profile

Tanja Jovanovic, Ph.D.
Professor

Psychiatry and Behavioral Neurosciences; Merril Palmer Skillman Institute

Research Interest

My research focuses on translational fear conditioning paradigms in patients with trauma-related disorders, using startle response as well as other psychophysiological and neuroimaging measures. My interests are in the association between genetic risk factors and psychopathology, with a focus on neurobiology, including fear-potentiated startle and brain function, with a focus on impaired inhibition processes. A central tenet of my research program is urban trauma in high-risk low income populations, and the intergenerational transmission of environmental and genetic risk factors on the developing brain.

Disease/Disorder

Trauma-related disorders; PTSD, anxiety, depression

Species

Human

Methods

fMRI, psychophysiology; fear-potentiated startle response.

Key Collaborators

Arash Javanbakht, M.D., Hilary Marusak, Ph.D., Christine Rabinak, Ph.D., Steve Ondersma, Ph.D., Kerry Ressler, Ph.D. (Harvard), Nicole Nugent, Ph.D. (Brown), Jennifer Stevens, Vasiliki Michopoulos, Barbara Rothbaum and Alicia Smith (Emory)

Research Connect

Publications

Division/Laboratory

Faculty Profile

Csaba Juhasz, M.D., Ph.D.
Professor

Pediatrics; Neurology

Research Interest

Functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders with a particular interest in the pathophysiology and progression of Sturge-Weber Syndrome.

Disease/Disorder

Epilepsy, brain tumors, Sturge-Weber Syndrome and developmental brain disorders.

Species

Human.

Methods

PET and MR imaging, EEG.

Key Collaborators

Sandeep Mittal, Otto Muzik, Jiani Hu, Eishi Asano, Jeong-Won Jeong, Michael Behen, Geoffrey Barger.

Research Connect

Publications

PET Center & Translational Imaging Laboratory

Division/Laboratory

Zhifeng Kou, Ph.D.
Associate Professor

Biomedical Engineering & Radiology

Research Interest

Advanced magnetic resonance imaging (MRI) of traumatic brain injury (TBI). We use advanced MRI to improve the detection and outcome prediction of brain trauma and further guide the clinical management and potential treatment of TBI.

Disease/Disorder

Traumatic brain injury

Species

Human and rodent animal models

Methods

Advanced MRI, including susceptibility weighted imaging and mapping, diffusion and perfusion imaging, MR spectroscopy imaging and functional imaging.

Key Collaborators

Robert Welch, M.D., John Woodard, Ph.D., Scott Millis, Ph.D., Randall Benson, M.D., John Cavanough, M.D., Robin Hanks, Ph.D.

Research Connect

Publications

Division/Laboratory

Laboratory

Donald M. Kuhn, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

We are interested in the role of non-neuronal cells in contributing to brain damage caused by drugs, disease and injury. We are also interested in the physiological and neurochemical roles played serotonin as determined through studies with a knockout mouse lacking brain serotonin (i.e., TPH2 knockout).

Disease/Disorder

Traumatic brain injury, parkinson's disease, depression and OCD.

Species

Mice, brain tissue and bacteria.

Methods

Neurochemistry, biochemistry, pharmacology, molecular biology, transgenic and knockout mouse models of CNS diseases.

Key Collaborators

Mariana Angoa-Perez, Michael Kane, David M. Thomas, Christian W. Kreipke, Alana Conti, Matthew Galloway, Shane Perrine.

Research Connect

Publications

Division/Laboratory

Molecular Neurobiology

David Ledgerwood, Ph.D.
Associate Professor

Psychiatry and Behavioral Neurosciences

Research Interest

Substance abuse treatment; Pathological gambling (problem gambling, compulsive gambling); Contingency management.

Disease/Disorder

Gambling disorder, nicotine dependence and substance use disorder.

Species

Human

Methods

Clinical Trials

Key Collaborators

Research Connect

Publications

Division/Laboratory

Problem Gambling

Jun Li, M.D., Ph.D.
Professor

Neurology; Translational Neuroscience Inititiative

Research Interest

Specializing in inherited peripheral nerve diseases and myelin biology. My research has two arms basic science and clinical research. Research focuses on acquiring a better understanding of Schwann cell biology, its applications in pathogenesis of inherited peripheral nervous diseases, and identifying molecular targets for therapeutic development.

Disease/Disorder

Inherited peripheral nerve diseases, motor neuron diseases

Species

Human, Mouse

Methods

Nerve conduction study, genetic variant analysis, Schwann cell / neuron co-culture, genetically manipulated animal models, cell biology / protein chemistry, peripheral nerve MRI

Key Collaborators

Who We Are

Narrative Bio

Publications

Division/Laboratory

Dr. Jun Li's Laboratory

Leslie Lundahl, Ph.D.
Assistant Professor

Psychiatry and Behavioral Neurosciences

Research Interest

Human behavioral pharmacology of drugs of abuse; Medications development for treatment of substance use disorders; Cannabis; Co-morbid psychiatric and substance use disorders.

Disease/Disorder

Species

Methods

Key Collaborators

Research Connect

Publications

Division/Laboratory

Mohammad Mehrmohammadi, Ph.D
Assistant Professor

Biomedical Engineering; Electrical and Computer Engineering

Research Interest

My research lab has been focused on developing novel, hybrid (combined ultrasound, photoacoustic, and elasticity imaging) to address unmet clinical needs such as early stage detection and staging of cancer (breast, ovarian, cervix), functional imaging of fetal and neonatal brain, and more accurate monitoring of fetal and maternal status during pregnancy, labor, and delivery.

Disease/Disorder

Perinatal Asphyxia, hypoxic ischemic encephalopathy

Species

Human, Sheep, Rabbit.

Methods

Ultrasound and Photoacoustic Imaging.

Key Collaborators

Dr. Siddhartha Tan, Dr. Sonia Hassan, Dr. Edgar Hernandez

Research Connect

Publications

Functional and Molecular Ultrasound Research Laboratory

Division/Laboratory

Otto Muzik, Ph.D.
Associate Professor

Pediatrics; Radiology; Neurology

Research Interest

PET imaging and Pediatric imaging.

Disease/Disorder

Epilepsy, Brown Adipose Tissue (BAT).

Species

Human.

Methods

PET and fMRI.

Key Collaborators

Vaibhav Diwadkar

Research Connect

Publications

Positron Emission Tomography (PET) Center

Division/Laboratory

Noa Ofen, Ph.D.
Assistant Professor

Institute of Gerontology; Pediatrics

Research Interest

The typical and atypical development of memory systems in the human brain. Functional and structural brain development. Relationship between variation in cognitive and brain development and genetic polymorphism.

Disease/Disorder

Developmental disorders, prematurity, schizophrenia.

Species

Human

Methods

MRI, fMRI, DTI, cognitive assessment, genetics.

Key Collaborators

Viabhav Diwadkar, Jeffrey Stanley, Naftali Raz, Joe Jacobson, Sandra Jacobson, Sarah Raz, Moriah Thomason.

Research Connect

Publications

Division/Laboratory

Ofen Lab

PubMed Search (past 5 years)

Shane A. Perrine, Ph.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Our laboratory focuses on the neuropsychopharmacology of drug addiction and co-occurring psychiatric conditions, namely depression and anxiety. The goal of my research is to elucidate the mechanisms by which drugs, particularly psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (ecstasy), affect neurochemistry and behavior. Using animal models, we seek to identify and understand the plasticity of the human brain in response to acute and repeated drug exposure, as well as, stressors and cues that lead to anxiety, depression and relapse to drug seeking. We are currently pursuing two major research studies: 1) Determine the neurochemical underpinnings that are disrupted by psychostimulants and lead to anxiety, depression and maladaptive reward behaviors; 2) Understand the neurobiological basis that underlies comorbidity of PTSD and drug abuse.

Disease/Disorder

Drug abuse and dependence, anxiety and depression.

Species

Rat

Methods

Rodent models/tests for reward, anxiety, and depression related behaviors, western blotting, ELISA, HPLC, and proton-magnetic resonance spectroscopy.

Key Collaborators

Matthew Galloway, Manuel Tancer, Mark Greenwald, Scott Bowen, Jeffrey Stanley, David Thomas, Donald Kuhn, Alana Conti, Pamela VandeVord, Michael Church, Bill Fantegrossi (U Arkansas), Leonard Howell (Emory U), Israel Liberzon (U Michigan), Mark Simmons (NEOUCOMP) and Ellen Unterwald (Temple U).

Research Connect

Publications

Division/Laboratory

Neuropharmacology of Addiction

Christine A. Rabinak, Ph.D.
Assistant Professor

Pharmacy Practice

Research Interest

Behavioral and neurobiological mechanisms of fear learning and memory; cannabinoid system and emotional processing; threat perception and regulations of affect; biomarkers of development and maintenance of anxiety disorders.

Disease/Disorder

Anxiety disorders, Trauma

Species

Human

Methods

fMRI, EEG, ERP, psychopharmacology, behavior and virtual reality.

Key Collaborators

Mark Greenwald (WSU), Jeff Stanley (WSU), K. Luan Phan (University of Illinois at Chicago), Mohammed Milad (MGH & Harvard), Greg H. Proudfit (SUNY Stony Brook), Moriah Thomason (WSU).

Research Connect

Publications

Translational Neuropsychopharmacology Laboratory

Division/Laboratory

Naftali Raz, Ph.D.
Professor

Institute of Gerontology; Psychology

Research Interest

Differential brain aging, its modification by genetic and pathophysiological factors, and its cognitive consequences.

Disease/Disorder

Cognitive aging

Species

Human

Methods

MRI and cognitive psychology.

Key Collaborators

E. Mark Haacke, Ulman Lindenberger (Max Planck Institute for Human Development, Berlin), Paolo Ghisletta (University of Geneva, Switzerland), Jeffrey Stanley.

Research Connect

Publications

Cognitive Neuroscience of Aging

Division/Laboratory

David Rosenberg, M.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Our lab is focused on uncovering the neurobiology of pediatric mental illness and translating those findings into advances in diagnostics and treatment.

Disease/Disorder

Obsessive Compulsive Disorder, major depression, and bipolar disorder

Species

Human (pediatric)

Methods

MRI, MRS, fMRI, genetics and cortisol.

Key Collaborators

Vaibhav Diwadkar, Jeffrey A Stanley, Paul Arnold & Jim Kennedy (University of Toronto), Greg Hanna (University of Michigan)

Research Connect

Publications

Child and Adolescent Research Services

Division/Laboratory

John SantaLucia, Ph.D.
Professor

Chemistry

Research Interest

NMR structure, Determination of RNA, Development of antibiotics.

Disease/Disorder

Bacterial infections. Combating drug resistance.

Species

E. Coli

Methods

NMR spectroscopy, x-ray crystallography, electron microscopy, FRET, and gel electrophoresis.

Key Collaborators

Philip R. Cunningham (WSU), Christine Chow (WSU).

Research Connect

Publications

Division/Laboratory

SantaLucia Laboratory

Jeffrey A. Stanley, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

To gain a greater understanding of the neural basis of neurodevelopment, aging and different disorder from the perspective of morphology, function and biochemistry using different MR methodologies such as ¹H and ³¹P MRS, functional MRS, myelin imaging and T1 mapping.

Disease/Disorder

schizophrenia, aging, ADHD, OCD, anxiety and mood disorders

Species

Human

Methods

MRS, fMRS, fMRI, myelin imaging, structural MRI

Key Collaborators

Vaibhav Diwadkar, Naftali Raz, Paul Burghardt, Mark Greenwald, Konasale M. Prasad (U. of Pittsburgh), Jair Soares (U. of Texas at Houston), Paolo Brambilla (U. of Milan)

Research Connect

Publications

Brain Imaging Research Division

Division/Laboratory

Eric Woodcock, M.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences;

Research Interest

Disease/Disorder

Species

Human

Methods

Key Collaborators

Research Connect

Publications

Division/Laboratory

Manuel Tancer, M.D.
Professor

Psychiatry & Behavioral Neurosciences; Pharmacology

Research Interest

Effects of MDMA (Ecstasy) measured with fMRI and MRS.

Disease/Disorder

Species

Human

Methods

Key Collaborators

Research Connect

Publications

Division/Laboratory

John Woodard, Ph.D.
Professor

Psychology

Research Interest

Neuropsychological and neuroimaging studies of memory in aging and dementia; Cognitive and health-related risk factors for late life anxiety; Detection and tracking of sport related concussion; Statistical and methodological issues in neuropsychological test construction and assessment.

Disease/Disorder

Species

Methods

Key Collaborators

Research Connect

Publications

Division/Laboratory

Psychology