Donald DeGracia
Laboratory Web Site
Research Interests
We study the mechanisms of cell death following brain ischemia and reperfusion, focusing on the causes and consequences of reperfusion-induced inhibition of protein synthesis, or translation arrest. This translation arrest appears to be part of the post-ischemic neuronal stress response. We have evaluated classical ribosome biochemistry, intracellular stress responses and most recently began investigating mRNA regulatory mechanisms, including stress granules and HuR granules. The lab is currently funded by the National Institute of Neurological Disorders and Stroke at the NIH.
Disease/Disorder
Brain ischemia and reperfusion injury: stroke, cardiac arrest and resuscitation brain damage.
Species
Rodents
Methods
Molecular biology.
Key Collaborators
Jose Rafols, Ph.D.
Publications
Courses taught by Donald DeGracia
Fall Term 2025 (future)
Fall Term 2024
- PSL7010 - Basic Graduate Physiology Lecture I
- PSL7011 - Basic Integrative Graduate Physiology I
- PSL7660 - Advanced Neurophysiology
- IBS7015 - Interdisciplinary Cell and Molecular Biology
- MGG7010 - Molecular Biology and Genetics