Facilities
The program office, mailbox and meeting room are located in the School of Medicine Scott Hall, room 2309. The office, which is staffed by an administrative assistant, is available for use by TNP faculty members and students. Applications will be processed through the School of Medicine Graduate Admissions office and forwarded to the program office.
PET Center
The PET Center is located in the Children’s Hospital of Michigan, Department of Pediatric Imaging, and is directed by Harry Chugani, M.D. and co-directed by Diane Chugani, Ph.D.
In addition to preclinical (microPET) imaging, the PET Center provides for clinical and research scans in patients and volunteers of all ages from Michigan and abroad. Children's Hospital of Michigan, Wayne State University, and other members of the Detroit Medical Center share this substantial resource with the community to detect seizure epileptic foci, to determine serotonin synthesis capacity in autism and tuberous sclerosis, to evaluate heart disorders and cardiac viability, and to identify malignant diseases or tumors and to monitor their therapy.
The PET Center includes substantial clinical, computer, data-analytic and radiochemical staff support. Radiotracers that are available include [11C]-flumazenil for measuring GABAA/benzodiazepine receptor function, [11C]-alpha-methyl-L-tryptophan for measuring serotonin synthesis, and [18F]-deoxyglucose for measuring energy metabolism.
Magnetic Resonance Center
The Vaitkevicius Magnetic Resonance Center (MR Center) is located in Harper Hospital.
E. Mark Haacke, Ph.D. directs the MR Research Facility within this MR Center. The MR Center’s mission is to develop and apply MR methods in pre-clinical and clinical populations to better understand human physiology and disease. The center promotes the use of MR-based methodologies to the WSU scientific community and supports the implementation of MR methods through education, assistance in experimental design, and data collection and analysis.
The MR Center encourages educational training for medical students, graduate students, postdoctoral fellows and visiting faculty. Major equipment includes two whole-body magnets for human use (1.5 Tesla clinical and 4.0 Tesla research-dedicated) and one magnet for animal use (4.7 Tesla), injection pumps for drug administration, and extensive computer storage and processing capabilities with linkage to the remainder of campus. Current MR-based imaging capabilities include structural MRI, functional MRI (fMRI), proton (1H) and phosphorous (31P) MR spectroscopy, and diffusion tensor imaging (DTI).
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| Structural MRI |
Functional MRI | Proton 1-H Spectroscopy | Phosphorous 31P Spectroscopy |
Psychiatry and Addiction Research Center (PARC)
The Department of Psychiatry and Behavioral Neurosciences operates the PARC. It is an inpatient/outpatient research unit located at Detroit Receiving Hospital.
It has six inpatient beds and four outpatient beds/procedure rooms, and is capable of supporting state-of-the-art clinical research studies. The PARC includes an on-site laboratory for biological sample preparation and storage. The unit is staffed by a research coordinator, psychiatric research nurses, research assistants, an occupational therapist, a social worker, a pharmacy technician, and is under the scientific and medical direction of Matcheri Keshavan, M.D., who is DPBN Associate Chair-Research.
This unit also houses the Clinical Electrophysiology Laboratory, which is directed by Nashaat Boutros, M.D., a dual board-certified psychiatrist and neurologist. The PARC is particularly well-suited to study the biologic basis of the major neuropsychiatric disorders, to conduct sleep research studies, and to develop innovative treatment strategies. Equipment located at the PARC can be used to conduct studies involving transcranial magnetic stimulation (TMS) and electroencephalography (EEG).
Brain Research and Interdisciplinary Neurosciences (BRAIN) Division
The BRAIN Division of the DPBN, which is co-directed by Dr. Matcheri Keshavan and Dr. Matthew Galloway, head of Preclinical Neuroimaging, provides technical resources to investigators who design, conduct and analyze neuroimaging data.
The resources of BRAIN support clinical and basic neuroimaging at WSU. In addition to the scanning equipment noted above, there is also an 11.7T Bruker scanner in Scott Hall. The division operates an extensive array of computers and software packages (e.g. SPM2, Brain Voyager) that are used for image analysis, particularly with MR-based studies.
BRAIN’s resources also include valuable tools in assessing seizure disorders, metabolic and mitochondrial disorders, childhood neurodegenerative disorders, hypoxic/ ischemic insults, animal models of substance use disorders, and many neuropsychiatric disorders. These include an image processing laboratory, considerable experience and ongoing research with proton and phosphorus magnetic resonance spectroscopy and spectroscopic imaging, providing high-resolution neurochemical images of brain, functional magnetic resonance imaging (fMRI) using BOLD (blood oxygenation level dependent) contrast.
The BRAIN laboratory is currently being renovated to include additional and/or improved space for other research complementing the imaging (e.g., behavioral assessment facility, HPLC, etc).
Laboratories
Additional laboratories that contribute to this program are located outside those facilities noted above. DPBN faculty members have laboratory space in the Substance Abuse Research Division’s Human Pharmacology Laboratory (Drs. Greenwald and Stine). Department of Neurology faculty members have laboratory space located in the Lande building (Dr. Maiese), Elliman building (Drs. Lisak, Dore-Duffy, Benjamins, Loeb, Garbern, Shy), and the Veterans Administration Medical Center (Drs. Adler and Li).