School of Medicine

Wayne State University School of Medicine

Traumatic Brain Injury and Post-Traumatic Stress Disorder

 

Deane Aikins, Ph.D. Psychiatry and Behavioral Neurosciences, Merrill Palmer Skillman Institute
Alana C. Conti, Ph.D. Neurological Surgery/Pediatric Neurosurgery
Donald J. DeGracia, Ph.D. Physiology
Paula Dore-Duffy, Ph.D. Neurology
E. Mark Haacke, Ph.D. Biomedical Engineering, Radiology
Zhifeng Kou, Ph.D. Radiology & Biomedical Engineering
Donald M. Kuhn, Ph.D. Psychiatry & Behavioral Neurosciences
Shane Perrine, Ph.D. Psychiatry & Behavioral Neurosciences
Christine A. Rabinak, Ph.D. Pharmacy Practice
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Deane Aikins, Ph.D.
Associate Professor

Psychiatry & Behavioral Neurosciences, Merrill Palmer Skillman Institute

Research Interest

Dr. Aikins is a neuroscience and clinical researcher interested in novel treatments of combat stress disorders, investigating both those who are resilient and those diagnosed with Posttraumatic Stress Disorder (PTSD), both in Veterans and military families. He is particularly interested in determining dementia risks in aging Veterans. His research focuses on neuroplasticity as a model for conceptualizing traumatic stress responses, risk and resilience models of PTSD and potential approaches for PTSD treatment.

Disease/Disorder

Posttraumatic Stress Disorder, Psychophysiological markers of deployment stress risk and resilience, Deployment stress and emotion regulation in Active Duty military families.

Species

Human

Methods

Psychophysiological markers of ANS activation, fMRI/MRI, diagnostic interviews.

Key Collaborators

Dr. Julie Wargo Aikins

Publications

PubMed Search (past 5 years)

Division/Laboratory

 

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Alana C. Conti, Ph.D.
Assistant Professor

Neurological Surgery, Pediatric Neurosurgery

Research Interest

Experiments designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol in the adult and juvenile brain. Additional studies focus on behavioral outcome following ethanol exposure. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in studies related to Fetal Alcohol Syndrome. Future projects will focus on development of a novel in vitro model of Fetal Alcohol Syndrome and defining the cellular mechanisms that regulate ethanol sensitivity following traumatic brain injury using both adult and juvenile mouse models.

Disease/Disorder

 Traumatic brain injury, fetal alcohol spectrum disorder and alcohol sensitivity.

Species

 Mice

Methods

Molecular Biology, Immunohistochemistry, Primary Neuronal Cultures, Behavioral Animal Models.

Key Collaborators

 Don Kuhn, Scott Bowen, Tiffany mathews, Shane Perrine, John Hannigan

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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Donald J. DeGracia, Ph.D.
Associate Professor

Physiology

Research Interest

We study the mechanisms of cell death following brain ischemia and reperfusion, focusing on the causes and consequences of reperfusion-induced inhibition of protein synthesis, or translation arrest.  This translation arrest appears to be part of the post-ischemic neuronal stress response.  We have evaluated classical ribosome biochemistry, intracellular stress responses and most recently began investigating mRNA regulatory mechanisms, including stress granules and HuR granules.  The lab is currently funded by the National Institute of Neurological Disorders and Stroke at the NIH.

Disease/Disorder

brain ischemia and reperfusion injury: stroke, cardiac arrest and resuscitation brain damage

Species

Rodents

Methods

Molecular biology.

Key Collaborators

Jose Rafols, Ph.D.

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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Paula Dore-Duffy, Ph.D.
Professor

Neurology

Research Interest

The role of the microvascular pericyte in vascular function and CNS vascular diseases.  The pericyte is an integral member of the blood brain barrier and neurovascular unit.  As such it functions as a regulator cell and is involved in regulation of focal capillary blood flow, angiogenesis, inflammation and is now known to be a source of adult stem cells. Ongoing studies include investigation of pericytes in stem cell therapeutic paradigms in EAE and Traumatic brain injury.

Disease/Disorder

Multiple sclerosis, traumatic brain injury and stroke

Species

Rats and mice.

Methods

Immune based techniques, cell culture, molecular biology, protein chemistry, FACs analysis, imaging and translational research.

Key Collaborators

Alexander Gow, Jose Rafols, William Brusilow and Richard Needleman, and outside the University Joseph Lamanna and Robert Miller at Case Western Reserve School of Medicine in Cleveland and Richard Milner at Scripps Research Institute and Gregory del Zoppo at the University of Washington in Seattle.

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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E. Mark Haacke, Ph.D.
Professor

Biomedical Engineering, Radiology

Research Interest

We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from multiple sclerosis to dementia.

Disease/Disorder

Stroke, trauma, cancer, multiple sclerosis and aging.

Species

Human, rats and mice.

Methods

MRI

Key Collaborators

Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern

Publications

PubMed Search (past 5 years).

Division/Laboratory

MR Research Facility

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Zhifeng Kou, Ph.D.
Assistant Professor

Radiology & Biomedical Engineering

Research Interest

Advanced magnetic resonance imaging (MRI) of traumatic brain injury (TBI). We use advanced MRI to improve the detection and outcome prediction of brain trauma and further guide the clinical management and potential treatment of TBI.

Disease/Disorder

Traumatic brain injury.

Species

Human, rodent animal models

Methods

Advanced MRI, including susceptibility weighted imaging and mapping, diffusion and perfusion imaging, MR spectroscopy imaging, and functional imaging.

Key Collaborators

Robert Welch, M.D., John Woodard, Ph.D., Scott Millis, Ph.D., Randall Benson, M.D., John Cavanaugh, M.D., Robin Hanks, Ph.D

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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Donald M. Kuhn, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

We are interested in the role of non-neuronal cells in contributing to brain damage caused by drugs, disease and injury. We are also interested in the physiological and neurochemical roles played serotonin as determined through studies with a knockout mouse lacking brain serotonin (i.e., TPH2 knockout).

Disease/Disorder

traumatic brain injury, parkinson’s disease, depression and OCD

Species

Mice, brain tissue and bacteria.

Methods

Neurochemistry, biochemistry, pharmacology, molecular biology, transgenic and knockout mouse models of CNS diseases

Key Collaborators

Mariana Angoa-Perez, Michael Kane, David M. Thomas, Alana Conti, Matthew Galloway, Shane Perrine

Publications

PubMed Search (past 5 years).

Division/Laboratory

DPBN

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Shane A. Perrine, Ph.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Our laboratory focuses on the neuropsychopharmacology of drug addiction and co-occurring psychiatric conditions, namely depression and anxiety. The goal of my research is to elucidate the mechanisms by which drugs, particularly psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (ecstasy), affect neurochemistry and behavior. Using animal models, we seek to identify and understand the plasticity of the human brain in response to acute and repeated drug exposure, as well as, stressors and cues that lead to anxiety, depression and relapse to drug seeking. We are currently pursuing two major research studies: 1) Determine the neurochemical underpinnings that are disrupted by psychostimulants and lead to anxiety, depression and maladaptive reward behaviors; 2) Understand the neurobiological basis that underlies comorbidity of PTSD and drug abuse.

Disease/Disorder

Drug abuse and dependence, anxiety and depression

Species

Rat

Methods

Rodent models/tests for reward, anxiety, and depression related behaviors, western blotting, ELISA, HPLC, and proton-magnetic resonance spectroscopy.

Key Collaborators

Matthew Galloway, Manuel Tancer, Mark Greenwald, Scott Bowen, Jeffrey Stanley, David Thomas, Donald Kuhn, Alana Conti, Pamela VandeVord, Michael Church, Bill Fantegrossi (U Arkansas), Leonard Howell (Emory U), Israel Liberzon (U Michigan), Mark Simmons (NEOUCOMP) and Ellen Unterwald (Temple U).

Publications

PubMed Search (past 5 years)

Division/Laboratory

BRAIN / Addiction Neuropharmacology Laboratory

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Christine A. Rabinak, Ph.D.
Assistant Professor

Pharmacy Practice

Research Interest

Behavioral and neurobiological mechanisms of fear learning and memory; cannabinoid system and emotional processing; threat perception and regulations of affect; biomarkers of development and maintenance of anxiety disorders.

Disease/Disorder

Anxiety disorders, Trauma

Species

Human

Methods

fMRI, EEG, ERP, psychopharmacology, behavio .

Key Collaborators

Mark Greenwald (WSU), Jeff Stanley (WSU), K. Luan Phan (University of Illinois at Chicago), Mohammed Milad (MGH & Harvard), Greg H. Proudfit (SUNY Stony Brook).

Publications

PubMed Search (past 5 years).

Division/Laboratory

Translational Neuropsychopharmacology Laboratory

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