School of Medicine

Wayne State University School of Medicine

Addiction and Substance Abuse


 

Scott Bowen, Ph.D. Psychology, Obstetrics and Gynecology
Alana C. Conti, Ph.D. Neurological Surgery / Pediatric Neurosurgery
Shane Perrine, Ph.D. Psychiatry & Behavioral Neurosciences
Mark Greenwald, Ph.D. Psychiatry & Behavioral Neurosciences, Psychology, Affiliated
Research Faculty in Psychology
Christine A. Rabinak, Ph.D. Pharmacy Practice
Manuel Tancer, M.D. Psychiatry & Behavioral Neurosciences, Pharmacology
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Scott Bowen, Ph.D.
Associate Professor

Psychology, Obstetrics and Gynecology

Research Interest

 

research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.

 

Disease/Disorder

 

 

 

Species

 

Rats and mice.

Methods

 

 

 

Key Collaborators

 

John Hannigan

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Behavioral Pharmacology and Toxicology Laboratory

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Alana C. Conti, Ph.D.
Assistant Professor

Neurological Surgery, Pediatric Neurosurgery

Research Interest

 

Experiments designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol in the adult and juvenile brain. Additional studies focus on behavioral outcome following ethanol exposure. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in studies related to Fetal Alcohol Syndrome. Future projects will focus on development of a novel in vitro model of Fetal Alcohol Syndrome and defining the cellular mechanisms that regulate ethanol sensitivity following traumatic brain injury using both adult and juvenile mouse models.

 

Disease/Disorder

 

 

 Traumatic brain injury, fetal alcohol spectrum disorder and alcohol sensitivity.

Species

 

 

 Mice

Methods

 

Molecular Biology, Immunohistochemistry, Primary Neuronal Cultures, Behavioral Animal Models.

 

Key Collaborators

 

 

 Don Kuhn, Scott Bowen, Tiffany mathews, Shane Perrine, John Hannigan

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Laboratory

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Shane A. Perrine, Ph.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Our laboratory focuses on the neuropsychopharmacology of drug addiction and co-occurring psychiatric conditions, namely depression and anxiety. The goal of my research is to elucidate the mechanisms by which drugs, particularly psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (ecstasy), affect neurochemistry and behavior. Using animal models, we seek to identify and understand the plasticity of the human brain in response to acute and repeated drug exposure, as well as, stressors and cues that lead to anxiety, depression and relapse to drug seeking. We are currently pursuing two major research studies: 1) Determine the neurochemical underpinnings that are disrupted by psychostimulants and lead to anxiety, depression and maladaptive reward behaviors; 2) Understand the neurobiological basis that underlies comorbidity of PTSD and drug abuse.

Disease/Disorder

 

 

Drug abuse and dependence, anxiety and depression

Species

 

 

Rat

Methods

 

Rodent models/tests for reward, anxiety, and depression related behaviors, western blotting, ELISA, HPLC, and proton-magnetic resonance spectroscopy.

 

Key Collaborators

 

 

Matthew Galloway, Manuel Tancer, Mark Greenwald, Scott Bowen, Jeffrey Stanley, David Thomas, Donald Kuhn, Alana Conti, Pamela VandeVord, Michael Church, Bill Fantegrossi (U Arkansas), Leonard Howell (Emory U), Israel Liberzon (U Michigan), Mark Simmons (NEOUCOMP) and Ellen Unterwald (Temple U).

Publications

 

PubMed Search (past 5 years)

Division/Laboratory

 

BRAIN / Addiction Neuropharmacology Laboratory

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Mark Greenwald, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences, Psychology; Affiliated Research Faculty in Psychology

Research Interest

 

Pharmacological, environmental and individual difference determinants of drug-seeking/use behavior (primary endpoint) and neural processes (measured with in vivo imaging methods) related to these behaviors.

 

Disease/Disorder

 

opioid, cocaine, marijuana, nicotine, and alcohol use disorders.

 

Species

 

Human.

Methods

 

PET (opioid and dopamine), 1H spectroscopy, fMRI, TMS and EEG.

 

Key Collaborators

 

Jon-Kar Zubieta (Univ. of Michigan: PET and fMRI), Jeffrey Stanley (1H spectroscopy), Nash Boutros (TMS), Tim Roehrs (EEG).

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Human Pharmacology Laboratory in the Substance Abuse Research Division

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Christine A. Rabinak, Ph.D.
Assistant Professor

Pharmacy Practice

Research Interest

 

Behavioral and neurobiological mechanisms of fear learning and memory; cannabinoid system and emotional processing; threat perception and regulations of affect; biomarkers of development and maintenance of anxiety disorders.

 

Disease/Disorder

 

 

Anxiety disorders, Trauma

Species

 

Human

Methods

 

fMRI, EEG, ERP, psychopharmacology, behavio .

 

Key Collaborators

 

Mark Greenwald (WSU), Jeff Stanley (WSU), K. Luan Phan (University of Illinois at Chicago), Mohammed Milad (MGH & Harvard), Greg H. Proudfit (SUNY Stony Brook).

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Translational Neuropsychopharmacology Laboratory

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Manuel Tancer, M.D.
Professor

Psychiatry & Behavioral Neurosciences, Pharmacology

Research Interest

 

Effects of MDMA (Ecstasy) measured with fMRI and MRS.

 

Disease/Disorder

 

 

 

Species

 

 

 

Methods

 

 

 

Key Collaborators

 

 

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Office of the Chair

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