School of Medicine

Wayne State University School of Medicine

Stroke

 

Donald J. DeGracia, Ph.D. Physiology
Paula Dore-Duffy, Ph.D. Neurology
E. Mark Haacke, Ph.D. Biomedical Engineering, Radiology
  back

 


 

Donald J. DeGracia, Ph.D.
Associate Professor

Physiology

Research Interest

We study the mechanisms of cell death following brain ischemia and reperfusion, focusing on the causes and consequences of reperfusion-induced inhibition of protein synthesis, or translation arrest.  This translation arrest appears to be part of the post-ischemic neuronal stress response.  We have evaluated classical ribosome biochemistry, intracellular stress responses and most recently began investigating mRNA regulatory mechanisms, including stress granules and HuR granules.  The lab is currently funded by the National Institute of Neurological Disorders and Stroke at the NIH.

Disease/Disorder

brain ischemia and reperfusion injury: stroke, cardiac arrest and resuscitation brain damage

Species

Rodents

Methods

Molecular biology.

Key Collaborators

Jose Rafols, Ph.D.

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

     top  back

 


 

Paula Dore-Duffy, Ph.D.
Professor

Neurology

Research Interest

The role of the microvascular pericyte in vascular function and CNS vascular diseases.  The pericyte is an integral member of the blood brain barrier and neurovascular unit.  As such it functions as a regulator cell and is involved in regulation of focal capillary blood flow, angiogenesis, inflammation and is now known to be a source of adult stem cells. Ongoing studies include investigation of pericytes in stem cell therapeutic paradigms in EAE and Traumatic brain injury.

Disease/Disorder

Multiple sclerosis, traumatic brain injury and stroke

Species

Rats and mice.

Methods

Immune based techniques, cell culture, molecular biology, protein chemistry, FACs analysis, imaging and translational research.

Key Collaborators

Alexander Gow, Jose Rafols, Christian Kreipke, William Brusilow and Richard Needleman, and outside the University Joseph Lamanna and Robert Miller at Case Western Reserve School of Medicine in Cleveland and Richard Milner at Scripps Research Institute and Gregory del Zoppo at the University of Washington in Seattle.

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

     top  back

  


 

E. Mark Haacke, Ph.D.
Professor

Biomedical Engineering, Radiology

Research Interest

We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from multiple sclerosis to dementia.

Disease/Disorder

Stroke, trauma, cancer, multiple sclerosis and aging.

Species

Human, rats and mice.

Methods

MRI

Key Collaborators

Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern

Publications

PubMed Search (past 5 years).

Division/Laboratory

MR Research Facility

     top  back