School of Medicine

Wayne State University School of Medicine

Prenatal Exposure Research

 

Scott Bowen, Ph.D. Psychology, Obstetrics and Gynecology
Alana C. Conti, Ph.D. Neurological Surgery/Pediatric Neurosurgery
Matthew P. Galloway, Ph.D. Psychiatry & Behavioral Neurosciences, Anesthesiology
John Hannigan, Ph.D. Obstetrics and Gynecology, Psychology
Joseph L. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
Sandra W. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
William Lyman, M.D. Pediatrics, Psychiatry & Behavioral Neurosciences
Noa Ofen, Ph.D. Institute of Gerontology, Pediatrics
Moriah Thomason, Ph.D. Pediatrics
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Scott Bowen, Ph.D.
Associate Professor

Psychology, Obstetrics and Gynecology

Research Interest

research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.

Disease/Disorder

 

Species

Rats and mice.

Methods

 

Key Collaborators

John Hannigan

Publications

PubMed Search (past 5 years).

Division/Laboratory

Behavioral Pharmacology and Toxicology Laboratory

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Alana C. Conti, Ph.D.
Assistant Professor

Neurological Surgery, Pediatric Neurosurgery

Research Interest

Experiments designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol in the adult and juvenile brain. Additional studies focus on behavioral outcome following ethanol exposure. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in studies related to Fetal Alcohol Syndrome. Future projects will focus on development of a novel in vitro model of Fetal Alcohol Syndrome and defining the cellular mechanisms that regulate ethanol sensitivity following traumatic brain injury using both adult and juvenile mouse models.

Disease/Disorder

 Traumatic brain injury, fetal alcohol spectrum disorder and alcohol sensitivity.

Species

 Mice

Methods

Molecular Biology, Immunohistochemistry, Primary Neuronal Cultures, Behavioral Animal Models.

Key Collaborators

 Don Kuhn, Scott Bowen, Tiffany mathews, Shane Perrine, John Hannigan

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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Matthew P. Galloway, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences, Anesthesiology

Research Interest

Neurochemical pharmacology of 1H-MRS.

Disease/Disorder

 

Species

Rats and mice.

Methods

 

Key Collaborators

 

Publications

PubMed Search (past 5 years).

Division/Laboratory

Molecular Neuroimaging Laboratory

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John Hannigan, Ph.D.
Professor

Obstetrics and Gynecology, Psychology

Research Interest

Neurobehavioral effects of prenatal drug and alcohol exposure.

 

Disease/Disorder

Fetal alcohol spectrum disorder. 

Species

Rats, mice and human.

Methods

MRI, MRS and fMRI. 

Key Collaborators

Lisa Chiodo, Jeffrey Stanley, Viabhav Diwadkar and Scott Moffat

Publications

PubMed Search (past 5 years).

Division/Laboratory

Neurobehavioral Teratology Laboratory

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Joseph L. Jacobson, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

Effects of prenatal exposure to alcohol and environmental contaminants (PCBs, mercury, lead) on infant and child development; research methods; study design.

Disease/Disorder

Fetal alcohol syndrome, fetal alcohol spectrum disorder, ADHD and alcohol abuse and dependence.

Species

Human.

Methods

Neuropsychological assessment, structural MRI, functional MRI and diffusion tensor imaging

Key Collaborators

Sandra W. Jacobson (all studies), Christopher Molteno and Ernesta Meintjes (Cape Town neuroimaging and neurobehavioral studies), Gina Muckle (Inuit studies)

Publications

PubMed Search (past 5 years).

Division/Laboratory

 

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Sandra W. Jacobson, Ph.D.
Professor

Psychiatry and Behavioral Neurosciences

Research Interest

Studying the effects of prenatal exposure to alcohol, cocaine, smoking and environmental contaminants (PCBs, mercury, lead) on infant and child development, using state-of-the-art neurobehavioral and neuroimaging outcome measures.

Disease/Disorder

Fetal alcohol syndrome (FAS), fetal alcohol spectrum disorder (FASD), attention deficit hyperactivity disorder (ADHD), alcohol abuse and dependence in pregnant women and adolescents.

Species

human

Methods

Eyeblink conditioning, fMRI, sMRI, DTI, infant and child neuropsychological assessment (standardized and nonstandardized tests) and  alcohol and drug ascertainment and dependence.

Key Collaborators

Joseph L. Jacobson (all studies), Mark Stanton (EBC), Christopher Molteno and Ernesta Meintjes (Cape Town fMRI and neurobehavioral studies), Gina Muckle (Inuit studies), Cynthia Bearer (meconium), Tim Oberlander and Joanne Weinberg (cortisol and pain reactivity), Charles Nelson (ERP)

Publications

PubMed Search (past 5 years).

Division/Laboratory

Child Development Research Laboratory

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William Lyman, M.D.
Professor

Pediatrics, Psychiatry & Behavioral Neurosciences

Research Interest

Stem cells: the good, the bad and the ugly. Good stem cells for nervous system. The bad stem cells in cancer. The ugly stem cells in kidney disease because of the dispute about whether they even exist.

Disease/Disorder

Fetal alcohol spectrum disorder, neuroblastoma, cerebral palsy, nephrotic syndrome and tubular necrosis

Species

Fetal human brain, blood and kidney tissues.

Methods

Cell, tissue culture and molecular biology and functional genomics.

Key Collaborators

S. Vangipuram, J. Wang, N. Choutai, G. Kapur, T. Mattoo, R. Novak, A. Dombkowski.

Publications

PubMed Search (past 5 years).

Division/Laboratory

Children’s Research Center of Michigan

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Noa Ofen, Ph.D.
Assistant Professor

Institute of Gerontology, Pediatrics

Research Interest

The typical and atypical development of memory systems in the human brain. Functional and structural brain development. Relationship between variation in cognitive and brain development and genetic polymorphism.

Disease/Disorder

Developmental disorders, prematurity and schizophrenia

Species

Human

Methods

MRI, fMRI, DTI, Cognitive assessment, Genetics.

Key Collaborators

Viabhav Diwadkar, Jeffrey Stanley, Naftali Raz, Joe Jacobson, Sandra Jacobson, Sarah Raz, Moriah Thomason

Publications

PubMed Search (past 5 years).

Division/Laboratory

Ofen Lab

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Moriah Thomason, Ph.D.
Assistant Professor

Pediatrics

Research Interest

Impact of the function and maturation of multiple, large-scale brain networks on the individual cognitive and emotional developmental trajectories of children. Relationship between variation in these trajectories and variation in individual brain chemistry and genetic composition. Current projects explore development of fetal neural networks and the impact of neural network development and genetic composition on pediatric anxiety.

Disease/Disorder

Developmental psychopathology.

Species

Human

Methods

fMRI, DTI, resting-state fMRI, endocrine and genetic techniques

Key Collaborators

David Rosenberg, Noa Ofen, Douglas Barnett, Gregory Dyson, Mary Roberts

Publications

PubMed Search (past 5 years).

Division/Laboratory

Developmental Neuroscience Lab

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