School of Medicine

Wayne State University School of Medicine

Neuropharmacology

 

Scott Bowen, Ph.D. Psychology, Obstetrics and Gynecology
Mark Greenwald, Ph.D. Psychiatry & Behavioral Neurosciences, Affiliated Research
Faculty in Psychology
Donald M. Kuhn, Ph.D. Psychiatry & Behavioral Neurosciences
Shane A. Perrine, Ph.D. Psychiatry & Behavioral Neurosciences
Manuel Tancer, M.D. Psychiatry & Behavioral Neurosciences, Pharmacology
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Scott Bowen, Ph.D.
Associate Professor

Psychology, Obstetrics and Gynecology

Research Interest

 

research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.

 

Disease/Disorder

 

 

 

Species

 

Rats and mice.

Methods

 

 

 

Key Collaborators

 

John Hannigan

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Behavioral Pharmacology and Toxicology Laboratory

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Mark Greenwald, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences, Psychology; Affiliated Research Faculty in Psychology

Research Interest

 

Pharmacological, environmental and individual difference determinants of drug-seeking/use behavior (primary endpoint) and neural processes (measured with in vivo imaging methods) related to these behaviors.

 

Disease/Disorder

 

opioid, cocaine, marijuana, nicotine, and alcohol use disorders.

 

Species

 

Human.

Methods

 

PET (opioid and dopamine), 1H spectroscopy, fMRI, TMS and EEG.

 

Key Collaborators

 

Jon-Kar Zubieta (Univ. of Michigan: PET and fMRI), Jeffrey Stanley (1H spectroscopy), Nash Boutros (TMS), Tim Roehrs (EEG).

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Human Pharmacology Laboratory in the Substance Abuse Research Division

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Donald M. Kuhn, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

We are interested in the role of non-neuronal cells in contributing to brain damage caused by drugs, disease and injury. We are also interested in the physiological and neurochemical roles played serotonin as determined through studies with a knockout mouse lacking brain serotonin (i.e., TPH2 knockout).

 

Disease/Disorder

 

traumatic brain injury, parkinson’s disease, depression and OCD

 

Species

 

Mice, brain tissue and bacteria.

Methods

 

Neurochemistry, biochemistry, pharmacology, molecular biology, transgenic and knockout mouse models of CNS diseases

 

Key Collaborators

 

Mariana Angoa-Perez, Michael Kane, David M. Thomas, Christian W. Kreipke, Alana Conti, Matthew Galloway, Shane Perrine

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

DPBN

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Shane A. Perrine, Ph.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Our laboratory focuses on the neuropsychopharmacology of drug addiction and co-occurring psychiatric conditions, namely depression and anxiety. The goal of my research is to elucidate the mechanisms by which drugs, particularly psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (ecstasy), affect neurochemistry and behavior. Using animal models, we seek to identify and understand the plasticity of the human brain in response to acute and repeated drug exposure, as well as, stressors and cues that lead to anxiety, depression and relapse to drug seeking. We are currently pursuing two major research studies: 1) Determine the neurochemical underpinnings that are disrupted by psychostimulants and lead to anxiety, depression and maladaptive reward behaviors; 2) Understand the neurobiological basis that underlies comorbidity of PTSD and drug abuse.

Disease/Disorder

 

 

Drug abuse and dependence, anxiety and depression

Species

 

 

Rat

Methods

 

Rodent models/tests for reward, anxiety, and depression related behaviors, western blotting, ELISA, HPLC, and proton-magnetic resonance spectroscopy.

 

Key Collaborators

 

 

Matthew Galloway, Manuel Tancer, Mark Greenwald, Scott Bowen, Jeffrey Stanley, David Thomas, Donald Kuhn, Alana Conti, Pamela VandeVord, Michael Church, Bill Fantegrossi (U Arkansas), Leonard Howell (Emory U), Israel Liberzon (U Michigan), Mark Simmons (NEOUCOMP) and Ellen Unterwald (Temple U).

Publications

 

PubMed Search (past 5 years)

Division/Laboratory

 

BRAIN / Addiction Neuropharmacology Laboratory

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Manuel Tancer, M.D.
Professor

Psychiatry & Behavioral Neurosciences, Pharmacology

Research Interest

 

Effects of MDMA (Ecstasy) measured with fMRI and MRS.

 

Disease/Disorder

 

 

 

Species

 

 

 

Methods

 

 

 

Key Collaborators

 

 

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Office of the Chair

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