School of Medicine

Wayne State University School of Medicine

Pediatric Research

 

Eishi Asano, M.D., Ph.D. Pediatrics, Neurology
Vaibhav A. Diwadkar, Ph.D. Psychiatry & Behavioral Neurosciences, Psychology
Alan Dombkowski, Ph.D. Pediatrics
John Hannigan, Ph.D. Obstetrics and Gynecology, Psychology
Joseph L. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
Sandra W. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
Csaba Juhasz, M.D., Ph.D. Pediatrics, Neurology
William Lyman, M.D. Pediatrics, Psychiatry & Behavioral Neurosciences
Otto Muzik, Ph.D. Pediatrics, Radiology, Neurology
Noa Ofen, Ph.D. Institute of Gerontology, Pediatrics
David Rosenberg, M.D. Psychiatry & Behavioral Neurosciences
Jeffrey A. Stanley, Ph.D. Psychiatry & Behavioral Neurosciences
Moriah Thomason, Ph.D. Pediatrics
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Eishi Asano, M.D., Ph.D.
Associate Professor

Pediatrics, Neurology

Research Interest

 

The core aim of the research pursued in my laboratory is to generate functional brain atlases in four dimensions, incorporating ‘space’ as well as ‘time’, using unique intracranial electrophysiological signals in patients who undergo surgical resection of a seizure focus and/or tumor.

 

Disease/Disorder

 

Epilepsy, Brain tumor.

 

Species

 

Human

Methods

 

EEG, Intracranial electrocorticography (ECoG), Cortico-cortical evoked potentials (CCEPs), Diffusion weighted tractography, 3D-surface rendered MRI, Neuropsychological tests, Eye tracking system.

 

Key Collaborators

 

Harry T. Chugani, MD, Csaba Juhasz, MD, PhD, Justin Jeong, PhD, Robert Rothermel, PhD, Sandeep Sood, MD, Noa Ofen, PhD, Otto Muzik, PhD.

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Department of Neurodiagnostics (EEG lab); Epilepsy surgery program

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Vaibhav A. Diwadkar, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences, Psychology

Research Interest

 

Using imaging to study the functional organization of cortico-striatal and cortico-limbic networks in normal development and to understand dysfunction in these circuits in vulnerable and disordered adolescent populations.

 

Disease/Disorder

 

Schizophrenia and mood disorders.

 

Species

 

Human

Methods

 

fMRI and neuropsychology tests.

 

Key Collaborators

 

Jeffrey Stanley, Nash Boutros, Bob Freedman, David Rosenberg, Otto Muzik, Harry Chugani, Diane Chugani, Joseph Jacobson, Sandra Jacobson

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Brain Imaging Research Division

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Alan Dombkowski, Ph.D.
Assistant Professor

Pediatrics

Research Interest

 

Under two federally funded grants we are studying molecular contributors to the epileptogenic potential of cortical tubers in tuberous sclerosis complex (TSC). We use genomic and bioinformatics technologies to characterize gene and protein expression patterns, microRNAs, mutations, and epigenetic modifications in human brain tissue resected for the treatment of intractable epilepsy. The outcomes of this research are expected to expand our understanding of epilepsy in TSC, identify novel therapeutic targets, and improve diagnostic imaging methods.

 

Disease/Disorder

 

Tuberous sclerosis complex, Epilepsy.

 

Species

 

Human (brain tissue, cell culture)

Methods

 

Next-generation sequencing, Microarrays, RT-PCR, Proteomics.

 

Key Collaborators

 

Harry Chugani, Diane Chugani, Eishi Asano, Paul Stemmer.

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Clinical Pharmacology and Toxicology

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John Hannigan, Ph.D.
Professor

Obstetrics and Gynecology, Psychology

Research Interest

 

Neurobehavioral effects of prenatal drug and alcohol exposure.

 

 

 

Disease/Disorder

 

 

Fetal alcohol spectrum disorder. 

Species

 

Rats, mice and human.

Methods

 

 

MRI, MRS and fMRI. 

Key Collaborators

 

 

Lisa Chiodo, Jeffrey Stanley, Viabhav Diwadkar and Scott Moffat

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Neurobehavioral Teratology Laboratory

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Joseph L. Jacobson, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Effects of prenatal exposure to alcohol and environmental contaminants (PCBs, mercury, lead) on infant and child development; research methods; study design.

 

Disease/Disorder

 

Fetal alcohol syndrome, fetal alcohol spectrum disorder, ADHD and alcohol abuse and dependence.

 

Species

 

Human.

Methods

 

Neuropsychological assessment, structural MRI, functional MRI and diffusion tensor imaging

 

Key Collaborators

 

Sandra W. Jacobson (all studies), Christopher Molteno and Ernesta Meintjes (Cape Town neuroimaging and neurobehavioral studies), Gina Muckle (Inuit studies)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

 

 

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Sandra W. Jacobson, Ph.D.
Professor

Psychiatry and Behavioral Neurosciences

Research Interest

 

Studying the effects of prenatal exposure to alcohol, cocaine, smoking and environmental contaminants (PCBs, mercury, lead) on infant and child development, using state-of-the-art neurobehavioral and neuroimaging outcome measures.

 

Disease/Disorder

 

Fetal alcohol syndrome (FAS), fetal alcohol spectrum disorder (FASD), attention deficit hyperactivity disorder (ADHD), alcohol abuse and dependence in pregnant women and adolescents.

 

Species

 

human

Methods

 

Eyeblink conditioning, fMRI, sMRI, DTI, infant and child neuropsychological assessment (standardized and nonstandardized tests) and  alcohol and drug ascertainment and dependence.

 

Key Collaborators

 

Joseph L. Jacobson (all studies), Mark Stanton (EBC), Christopher Molteno and Ernesta Meintjes (Cape Town fMRI and neurobehavioral studies), Gina Muckle (Inuit studies), Cynthia Bearer (meconium), Tim Oberlander and Joanne Weinberg (cortisol and pain reactivity), Charles Nelson (ERP)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Child Development Research Laboratory

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Csaba Juhasz, M.D., Ph.D.
Professor

Pediatrics, Neurology

Research Interest

 

Functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders with a particular interest in the pathophysiology and progression of Sturge-Weber Syndrome.

 

Disease/Disorder

 

Epilepsy, brain tumors,  sturge-weber syndrome and developmental brain disorders

 

Species

 

Human.

Methods

 

PET imaging and EEG.

 

Key Collaborators

 

 

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

PET Center, Children's Hospital of Michigan

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William Lyman, M.D.
Professor

Pediatrics, Psychiatry & Behavioral Neurosciences

Research Interest

 

Stem cells: the good, the bad and the ugly. Good stem cells for nervous system. The bad stem cells in cancer. The ugly stem cells in kidney disease because of the dispute about whether they even exist.

Disease/Disorder

 

Fetal alcohol spectrum disorder, neuroblastoma, cerebral palsy, nephrotic syndrome and tubular necrosis

 

Species

 

Fetal human brain, blood and kidney tissues.

Methods

 

Cell, tissue culture and molecular biology and functional genomics.

 

Key Collaborators

 

S. Vangipuram, J. Wang, N. Choutai, G. Kapur, T. Mattoo, R. Novak, A. Dombkowski.

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Children’s Research Center of Michigan

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Otto Muzik, Ph.D.
Associate Professor

Pediatrics, Radiology, Neurology

Research Interest

 

PET imaging and Pediatric imaging.

 

Disease/Disorder

 

Epilepsy.

 

Species

 

Human.

Methods

 

 

PET 

Key Collaborators

 

 

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Laboratory

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Noa Ofen, Ph.D.
Assistant Professor

Institute of Gerontology, Pediatrics

Research Interest

 

The typical and atypical development of memory systems in the human brain. Functional and structural brain development. Relationship between variation in cognitive and brain development and genetic polymorphism.

 

Disease/Disorder

 

Developmental disorders, prematurity and schizophrenia

 

Species

 

 

Human

Methods

 

MRI, fMRI, DTI, Cognitive assessment, Genetics.

 

Key Collaborators

 

Viabhav Diwadkar, Jeffrey Stanley, Naftali Raz, Joe Jacobson, Sandra Jacobson, Sarah Raz, Moriah Thomason

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Ofen Lab

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David Rosenberg, M.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Our lab is focused on uncovering the neurobiology of pediatric mental illness and translating those findings into advances in diagnostics and treatment.

 

Disease/Disorder

 

Obsessive Compulsive Disorder, major depression, and bipolar disorder

 

Species

 

Human (pediatric)

Methods

 

MRI, MRS, fMRI, genetics and cortisol.

 

Key Collaborators

 

Jeffrey A Stanley, PhD (WSU), Paul Arnold, MD & Jim Kennedy (University of Toronto), Greg Hanna (University of Michigan)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Child and Adolescent Research Services

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Jeffrey A. Stanley, Ph.D.
Associate Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

To gain a greater understanding of neurodevelopmental effects of morphology, function and biochemistry on childhood disorders such as ADHD using different MR methodologies.

 

Disease/Disorder

 

ADHD, schizophrenia, anxiety and mood disorders.

 

Species

 

Human (pediatric)

Methods

 

Different MR methodologies.

 

Key Collaborators

 

Vaibhav Diwadkar, John Hannigan, Mark Greenwald, Nash Boutros, Brian Martis (U. of Michigan), Jair Soares (U. of Texas at Houston)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Brain Imaging Research Division

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Moriah Thomason, Ph.D.
Assistant Professor

Pediatrics

Research Interest

 

Impact of the function and maturation of multiple, large-scale brain networks on the individual cognitive and emotional developmental trajectories of children. Relationship between variation in these trajectories and variation in individual brain chemistry and genetic composition. Current projects explore development of fetal neural networks and the impact of neural network development and genetic composition on pediatric anxiety.

 

Disease/Disorder

 

Developmental psychopathology.

 

Species

 

Human

Methods

 

fMRI, DTI, resting-state fMRI, endocrine and genetic techniques

 

Key Collaborators

 

David Rosenberg, Noa Ofen, Douglas Barnett, Gregory Dyson, Mary Roberts

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Developmental Neuroscience Lab

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