School of Medicine

Wayne State University School of Medicine

Brain Ischemia and Reperfusion



Donald J. DeGracia, Ph.D. Physiology                                      
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Donald J. DeGracia, Ph.D.
Associate Professor

Physiology

Research Interest

We study the mechanisms of cell death following brain ischemia and reperfusion, focusing on the causes and consequences of reperfusion-induced inhibition of protein synthesis, or translation arrest.  This translation arrest appears to be part of the post-ischemic neuronal stress response.  We have evaluated classical ribosome biochemistry, intracellular stress responses and most recently began investigating mRNA regulatory mechanisms, including stress granules and HuR granules.  The lab is currently funded by the National Institute of Neurological Disorders and Stroke at the NIH.

Disease/Disorder

brain ischemia and reperfusion injury: stroke, cardiac arrest and resuscitation brain damage

Species

Rodents

Methods

Molecular biology.

Key Collaborators

Jose Rafols, Ph.D.

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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