School of Medicine

Wayne State University School of Medicine

Epilepsy

 

Eishi Asano, M.D., Ph.D. Pediatrics, Neurology
Alan Dombkowski, Ph.D. Pediatrics
Csaba Juhasz, M.D., Ph.D. Pediatrics, Neurology
Otto Muzik, Ph.D. Pediatrics, Radiology, Neurology
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Eishi Asano, M.D., Ph.D.
Associate Professor

Pediatrics, Neurology

Research Interest

 

The core aim of the research pursued in my laboratory is to generate functional brain atlases in four dimensions, incorporating ‘space’ as well as ‘time’, using unique intracranial electrophysiological signals in patients who undergo surgical resection of a seizure focus and/or tumor.

 

Disease/Disorder

 

Epilepsy, Brain tumor.

 

Species

 

Human

Methods

 

EEG, Intracranial electrocorticography (ECoG), Cortico-cortical evoked potentials (CCEPs), Diffusion weighted tractography, 3D-surface rendered MRI, Neuropsychological tests, Eye tracking system.

 

Key Collaborators

 

Harry T. Chugani, MD, Csaba Juhasz, MD, PhD, Justin Jeong, PhD, Robert Rothermel, PhD, Sandeep Sood, MD, Noa Ofen, PhD, Otto Muzik, PhD.

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Department of Neurodiagnostics (EEG lab); Epilepsy surgery program

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Alan Dombkowski, Ph.D.
Assistant Professor

Pediatrics

Research Interest

 

Under two federally funded grants we are studying molecular contributors to the epileptogenic potential of cortical tubers in tuberous sclerosis complex (TSC). We use genomic and bioinformatics technologies to characterize gene and protein expression patterns, microRNAs, mutations, and epigenetic modifications in human brain tissue resected for the treatment of intractable epilepsy. The outcomes of this research are expected to expand our understanding of epilepsy in TSC, identify novel therapeutic targets, and improve diagnostic imaging methods.

 

Disease/Disorder

 

Tuberous sclerosis complex, Epilepsy.

 

Species

 

Human (brain tissue, cell culture)

Methods

 

Next-generation sequencing, Microarrays, RT-PCR, Proteomics.

 

Key Collaborators

 

Harry Chugani, Diane Chugani, Eishi Asano, Paul Stemmer.

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Clinical Pharmacology and Toxicology

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Csaba Juhasz, M.D., Ph.D.
Professor

Pediatrics, Neurology

Research Interest

 

Functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders with a particular interest in the pathophysiology and progression of Sturge-Weber Syndrome.

 

Disease/Disorder

 

Epilepsy, brain tumors,  sturge-weber syndrome and developmental brain disorders

 

Species

 

Human.

Methods

 

PET imaging and EEG.

 

Key Collaborators

 

 

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

PET Center, Children's Hospital of Michigan

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Otto Muzik, Ph.D.
Associate Professor

Pediatrics, Radiology, Neurology

Research Interest

 

PET imaging and Pediatric imaging.

 

Disease/Disorder

 

Epilepsy.

 

Species

 

Human.

Methods

 

 

PET 

Key Collaborators

 

 

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Laboratory

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