School of Medicine

Wayne State University School of Medicine

Brain Development and Aging and Related Disorders

 

Scott Bowen, Ph.D. Psychology, Obstetrics and Gynecology
Jessica S. Damoiseaux, Ph.D. Psychology, Institute of Gerontology
Vaibhav Diwadkar, Ph.D. Psychiatry & Behavioral Neurosciences
Alexander Gow, Ph.D. Center for Molecular Medicine and Genetics
E. Mark Haacke, Ph.D. Biomedical Engineering, Radiology
Joseph L. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
Sandra W. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
Csaba Juhasz, M.D., Ph.D. Pediatrics, Neurology
Noa Ofen, Ph.D. Institute of Gerontology, Pediatrics
Naftali Raz, Ph.D. Institute of Gerontology, Psychology
Jeffrey A. Stanley, Ph.D. Psychiatry & Behavioral Neurosciences
Moriah Thomason, Ph.D. Pediatrics
John Woodard, Ph.D. Psychology
  back

 

 

  


 

 

Scott Bowen, Ph.D.
Associate Professor

Psychology, Obstetrics and Gynecology

Research Interest

 

research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.

 

Disease/Disorder

 

 

 

Species

 

Rats and mice.

Methods

 

 

 

Key Collaborators

 

John Hannigan

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Behavioral Pharmacology and Toxicology Laboratory

     top  back

 

 


 

 

Jessica S. Damoiseaux, Ph.D.
Assistant Professor

Psychology, Institute of Gerontology

Research Interest

 

Changes in functional and structural brain connectivity in normal and abnormal aging, with a specific focus on the early detection of Alzheimer’s disease.

 

Disease/Disorder

 

Healthy aging and Alzheimer’s disease.

 

Species

 

Human

Methods

 

functional MRI; diffusion MRI; neuropsychological assessment.

 

Key Collaborators

 

Serge Rombouts and Jeroen van der Grond, Leiden Institute for Brain and Cognition, the Netherlands.

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Connect Lab

     top  back

 

  


 

 

Vaibhav A. Diwadkar, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences, Psychology

Research Interest

 

Using imaging to study the functional organization of cortico-striatal and cortico-limbic networks in normal development and to understand dysfunction in these circuits in vulnerable and disordered adolescent populations.

 

Disease/Disorder

 

Schizophrenia and mood disorders.

 

Species

 

Human

Methods

 

fMRI and neuropsychology tests.

 

Key Collaborators

 

Jeffrey Stanley, Nash Boutros, Bob Freedman, David Rosenberg, Otto Muzik, Harry Chugani, Diane Chugani, Joseph Jacobson, Sandra Jacobson

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Brain Imaging Research Division

     top  back

 

  


 

 

Alexander Gow, Ph.D.
Professor

Center for Molecular Medicine and Genetics, Pediatrics, Neurology

Research Interest

 

White matter disease and relevance to cognitive deficits.

 

Disease/Disorder

 

Depression, multiple sclerosis, Pelizaeus-Merzbacher, Auditory Processing Disorder.

 

Species

 

Mouse and Human

Methods

 

Knockout and transgenic mice, confocal and electron microscopy, psychoacoustics, behavior, MRI ad MRS, biochemistry, microarrays, computational modeling, drug testing to ameliorate neurodegeneration.

 

Key Collaborators

 

Robert Skoff, Anatomy and Cell Biology (WSU); Zhengqing Hu, Otolaryngology (WSU); Paula Dore-Duffy, Neurology (WSU); Jeff Stanley, Psychiatry (WSU); Shane Perrine, Psychiatry (WSU); Matthew Galloway, Psychiatry (WSU); Mark Cheng, Electrical Engineering (WSU)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Laboratory of Molecular and Cellular Neuroscience

     top  back

 

  


 

 

Joseph L. Jacobson, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Effects of prenatal exposure to alcohol and environmental contaminants (PCBs, mercury, lead) on infant and child development; research methods; study design.

 

Disease/Disorder

 

Fetal alcohol syndrome, fetal alcohol spectrum disorder, ADHD and alcohol abuse and dependence.

 

Species

 

Human.

Methods

 

Neuropsychological assessment, structural MRI, functional MRI and diffusion tensor imaging

 

Key Collaborators

 

Sandra W. Jacobson (all studies), Christopher Molteno and Ernesta Meintjes (Cape Town neuroimaging and neurobehavioral studies), Gina Muckle (Inuit studies)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

 

 

     top  back

 

  


 

 

Sandra W. Jacobson, Ph.D.
Professor

Psychiatry and Behavioral Neurosciences

Research Interest

 

Studying the effects of prenatal exposure to alcohol, cocaine, smoking and environmental contaminants (PCBs, mercury, lead) on infant and child development, using state-of-the-art neurobehavioral and neuroimaging outcome measures.

 

Disease/Disorder

 

Fetal alcohol syndrome (FAS), fetal alcohol spectrum disorder (FASD), attention deficit hyperactivity disorder (ADHD), alcohol abuse and dependence in pregnant women and adolescents.

 

Species

 

human

Methods

 

Eyeblink conditioning, fMRI, sMRI, DTI, infant and child neuropsychological assessment (standardized and nonstandardized tests) and  alcohol and drug ascertainment and dependence.

 

Key Collaborators

 

Joseph L. Jacobson (all studies), Mark Stanton (EBC), Christopher Molteno and Ernesta Meintjes (Cape Town fMRI and neurobehavioral studies), Gina Muckle (Inuit studies), Cynthia Bearer (meconium), Tim Oberlander and Joanne Weinberg (cortisol and pain reactivity), Charles Nelson (ERP)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Child Development Research Laboratory

     top  back

 

  


 

 

Csaba Juhasz, M.D., Ph.D.
Professor

Pediatrics, Neurology

Research Interest

 

Functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders with a particular interest in the pathophysiology and progression of Sturge-Weber Syndrome.

 

Disease/Disorder

 

Epilepsy, brain tumors,  sturge-weber syndrome and developmental brain disorders

 

Species

 

Human.

Methods

 

PET imaging and EEG.

 

Key Collaborators

 

 

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

PET Center, Children's Hospital of Michigan

     top  back

 

 

  


 

 

E. Mark Haacke, Ph.D.
Professor

Biomedical Engineering, Radiology

Research Interest

 

We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from multiple sclerosis to dementia.

 

Disease/Disorder

 

Stroke, trauma, cancer, multiple sclerosis and aging.

 

Species

 

Human, rats and mice.

Methods

 

MRI

 

Key Collaborators

 

Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

MR Research Facility

    top  back

 

  


 

 

Noa Ofen, Ph.D.
Assistant Professor

Institute of Gerontology, Pediatrics

Research Interest

 

The typical and atypical development of memory systems in the human brain. Functional and structural brain development. Relationship between variation in cognitive and brain development and genetic polymorphism.

 

Disease/Disorder

 

Developmental disorders, prematurity and schizophrenia

 

Species

 

 

Human

Methods

 

MRI, fMRI, DTI, Cognitive assessment, Genetics.

 

Key Collaborators

 

Viabhav Diwadkar, Jeffrey Stanley, Naftali Raz, Joe Jacobson, Sandra Jacobson, Sarah Raz, Moriah Thomason

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Ofen Lab

    top  back

 

  


 

 

Naftali Raz, Ph.D.
Professor

Institute of Gerontology, Psychology

Research Interest

 

Differential brain aging, its modification by genetic and pathophysiological factors, and its cognitive consequences.

 

Disease/Disorder

 

 

 

Species

 

Human

Methods

 

MRI and cognitive psychology.

 

Key Collaborators

 

E. Mark Haacke (WSU), Ulman Lindenberger (Max Planck Institute for Human Development, Berlin),  Paolo Ghisletta (University of Geneva, Switzerland).

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Cognitive Neuroscience of Aging Lab

    top  back

 

  


 

 

Jeffrey A. Stanley, Ph.D.
Associate Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

To gain a greater understanding of neurodevelopmental effects of morphology, function and biochemistry on childhood disorders such as ADHD using different MR methodologies.

 

Disease/Disorder

 

ADHD, schizophrenia, anxiety and mood disorders.

 

Species

 

Human (pediatric)

Methods

 

Different MR methodologies.

 

Key Collaborators

 

Vaibhav Diwadkar, John Hannigan, Mark Greenwald, Nash Boutros, Brian Martis (U. of Michigan), Jair Soares (U. of Texas at Houston)

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Brain Imaging Research Division

     top  back

 

 


 

 

Moriah Thomason, Ph.D.
Assistant Professor

Pediatrics

Research Interest

 

Impact of the function and maturation of multiple, large-scale brain networks on the individual cognitive and emotional developmental trajectories of children. Relationship between variation in these trajectories and variation in individual brain chemistry and genetic composition. Current projects explore development of fetal neural networks and the impact of neural network development and genetic composition on pediatric anxiety.

 

Disease/Disorder

 

Developmental psychopathology.

 

Species

 

Human

Methods

 

fMRI, DTI, resting-state fMRI, endocrine and genetic techniques

 

Key Collaborators

 

David Rosenberg, Noa Ofen, Douglas Barnett, Gregory Dyson, Mary Roberts

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Developmental Neuroscience Lab

     top  back