Parkinson's Disease
| Donald M. Kuhn, Ph.D. | Psychiatry & Behavioral Neurosciences |
| Robert Mackenzie, Ph.D. | Psychiatry & Behavioral Neurosciences |
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Donald M. Kuhn, Ph.D. Psychiatry & Behavioral Neurosciences |
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Research Interest |
We are interested in the role of non-neuronal cells in contributing to brain damage caused by drugs, disease and injury. We are also interested in the physiological and neurochemical roles played serotonin as determined through studies with a knockout mouse lacking brain serotonin (i.e., TPH2 knockout). |
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Disease/Disorder |
traumatic brain injury, parkinson’s disease, depression and OCD |
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Species |
Mice, brain tissue and bacteria. |
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Methods |
Neurochemistry, biochemistry, pharmacology, molecular biology, transgenic and knockout mouse models of CNS diseases |
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Key Collaborators |
Mariana Angoa-Perez, Michael Kane, David M. Thomas, Alana Conti, Matthew Galloway, Shane Perrine |
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Robert Mackenzie, Ph.D. Psychiatry & Behavioral Neurosciences |
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Research Interest |
The role of hypothalamic and dopamine neurons in energy homeostasis. |
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Disease/Disorder |
Obesity and Parkinson’s disease. |
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Species |
Transgenic mice. |
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Methods |
Cre-lox technology, gene targeting through modified bacterial artificial chromosomes (BACs) and laser capture microdissection. |
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Key Collaborators |
Greg Barsh (Stanford) |
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