School of Medicine

Wayne State University School of Medicine

Parkinson's Disease

 

Donald M. Kuhn, Ph.D. Psychiatry & Behavioral Neurosciences
Robert Mackenzie, Ph.D. Psychiatry & Behavioral Neurosciences
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Donald M. Kuhn, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

We are interested in the role of non-neuronal cells in contributing to brain damage caused by drugs, disease and injury. We are also interested in the physiological and neurochemical roles played serotonin as determined through studies with a knockout mouse lacking brain serotonin (i.e., TPH2 knockout).

Disease/Disorder

traumatic brain injury, parkinson’s disease, depression and OCD

Species

Mice, brain tissue and bacteria.

Methods

Neurochemistry, biochemistry, pharmacology, molecular biology, transgenic and knockout mouse models of CNS diseases

Key Collaborators

Mariana Angoa-Perez, Michael Kane, David M. Thomas, Alana Conti, Matthew Galloway, Shane Perrine

Publications

PubMed Search (past 5 years).

Division/Laboratory

DPBN

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Robert Mackenzie, Ph.D.
Associate Professor

Psychiatry & Behavioral Neurosciences

Research Interest

The role of hypothalamic and dopamine neurons in energy homeostasis.

Disease/Disorder

Obesity and Parkinson’s disease.

Species

Transgenic mice.

Methods

Cre-lox technology, gene targeting through modified bacterial artificial chromosomes (BACs) and laser capture microdissection.

Key Collaborators

Greg Barsh (Stanford)

Publications

PubMed Search (past 5 years).

Division/Laboratory

CIMER

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