School of Medicine

Wayne State University School of Medicine

Multiple Sclerosis and White Matter Disorders

 

Joyce Benjamins, Ph.D Neurology, Biochemistry, Immunology, Microbiology
Paula Dore-Duffy, Ph.D. Neurology
Alexander Gow, Ph.D. Center for Molecular Medicine and Genetics
E. Mark Haacke, Ph.D. Biomedical Engineering, Radiology
Jiani Hu, Ph.D. Radiology
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Joyce Benjamins, Ph.D.
Professor and Associate Chair for Research

Neurology

Research Interest

Research interests include regulation of myelination, glial differentiation, and the roles of metabotropic glutamate receptors and the kynurenine pathway in mediating oligodendroglial injury. One current project investigates the effects of glutamate receptor agonists and antagonists on disease outcome in EAE, an animal model of multiple sclerosis. A collaboration with Dr. Lisak utilizes gene arrays to investigate the effects of cytokines on gene expression in CNS neurons and glia.

Disease/Disorder

Diseases affecting myelin, including multiple sclerosis, genetic disorders and neurodegenerative disorders. 

Species

Rats and mice.

Methods

Western blotting, PCR, gene array analysis and immunocytochemistry.

Key Collaborators

Robert Lisak and John Kamholz

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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Paula Dore-Duffy, Ph.D.
Professor

Neurology

Research Interest

The role of the microvascular pericyte in vascular function and CNS vascular diseases.  The pericyte is an integral member of the blood brain barrier and neurovascular unit.  As such it functions as a regulator cell and is involved in regulation of focal capillary blood flow, angiogenesis, inflammation and is now known to be a source of adult stem cells. Ongoing studies include investigation of pericytes in stem cell therapeutic paradigms in EAE and Traumatic brain injury.

Disease/Disorder

Multiple sclerosis, traumatic brain injury and stroke

Species

Rats and mice.

Methods

Immune based techniques, cell culture, molecular biology, protein chemistry, FACs analysis, imaging and translational research.

Key Collaborators

Alexander Gow, Jose Rafols, Christian Kreipke, William Brusilow and Richard Needleman, and outside the University Joseph Lamanna and Robert Miller at Case Western Reserve School of Medicine in Cleveland and Richard Milner at Scripps Research Institute and Gregory del Zoppo at the University of Washington in Seattle.

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory

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Alexander Gow, Ph.D.
Professor

Center for Molecular Medicine and Genetics, Pediatrics, Neurology

Research Interest

White matter disease and relevance to cognitive deficits.

Disease/Disorder

Depression, multiple sclerosis, Pelizaeus-Merzbacher, Auditory Processing Disorder.

Species

Mouse and Human

Methods

Knockout and transgenic mice, confocal and electron microscopy, psychoacoustics, behavior, MRI ad MRS, biochemistry, microarrays, computational modeling, drug testing to ameliorate neurodegeneration.

Key Collaborators

Robert Skoff, Anatomy and Cell Biology (WSU); Zhengqing Hu, Otolaryngology (WSU); Paula Dore-Duffy, Neurology (WSU); Jeff Stanley, Psychiatry (WSU); Shane Perrine, Psychiatry (WSU); Matthew Galloway, Psychiatry (WSU); Mark Cheng, Electrical Engineering (WSU)

Publications

PubMed Search (past 5 years).

Division/Laboratory

Laboratory of Molecular and Cellular Neuroscience

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E. Mark Haacke, Ph.D.
Professor

Biomedical Engineering, Radiology

Research Interest

We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from multiple sclerosis to dementia.

Disease/Disorder

Stroke, trauma, cancer, multiple sclerosis and aging.

Species

Human, rats and mice.

Methods

MRI

Key Collaborators

Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern

Publications

PubMed Search (past 5 years).

Division/Laboratory

MR Research Facility

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Jiani Hu, Ph.D.
Associate Professor

Radiology

Research Interest

Exploring in vivo MR properties of lesions for diagnosis, prognosis and treatment follow-up using the state-of-art in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques.

Disease/Disorder

Neurological disorders and cancers.

Species

Human and small animals.

Methods

MRI and MRS.

Key Collaborators

Mark Haacke

Publications

PubMed Search (past 5 years).

Division/Laboratory

MR Research Facility

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